biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
enhanced validation
RNAi knockdown
orthogonal RNAseq
Learn more about Antibody Enhanced Validation
technique(s)
immunoblotting: 0.04-0.4 μg/mL, immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:50-1:200
immunogen sequence
EQEKRAQQPAPAPAPLGTPVKQENSFSSCQLSQQPLGPAHPFNPSLAAPATNHIDPCAVAPGPPSVVVKQEALQPEPEPVPAPQLLLGPQGPSLIKGVAPPTLITDSTGTHLVLTVTNKNADSPG
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MKL1(57591)
General description
MKL1(巨核细胞白血病(易位)因子1)基因定位于人类染色体22q13.2上,属于心肌素相关转录共激活因子家族。存在于细胞质和细胞核中,在人类组织中广泛表达。
Immunogen
巨核细胞白血病(易位)因子1重组蛋白质抗原表位标签(PrEST)
Application
成功使用该抗体的应用以及相关的同行评审论文如下所示。
免疫荧光分析(1篇论文)
免疫荧光分析(1篇论文)
由Atlas Antibodies提供技术支持的所有Prestige Antibodies®抗体均由人类蛋白质图集(HPA)项目开发和验证。每种抗体都通过针对数百种正常和疾病组织的免疫组织化学进行测试。通过单击图像库链接,可以在人类蛋白质图谱(HPA)站点上查看这些图像。我们还提供Prestige Antibodies® 抗体的实验方案和其他有用信息。
兔抗-MKL1抗体已用于免疫荧光分析。
兔抗-MKL1抗体已用于免疫荧光分析。
Biochem/physiol Actions
MKL1(巨核细胞白血病(易位)因子1)是一种转录共激活因子。G-肌动蛋白与MKL1相互作用,防止其结合转录因子SRF(血清反应因子)。脱离G-肌动蛋白的MKL1会与SRF相互作用,调控细胞骨架蛋白表达。MKL1也参与骨骼肌、心肌和平滑肌分化。还可增强肿瘤细胞侵袭和转移。
Features and Benefits
Prestige Antibodies®是经过高度表征和广泛验证的抗体,同时还有一个优点是其每个靶标的所有可用表征数据都可以通过位于此页面顶部产品名称下方的人类蛋白质图谱门户进行访问。Prestige Antibodies®对其他蛋白质的独特性和低交叉反应性是通过严密的抗原区域选择、亲和纯化和严格的选择来实现的。每种Prestige 抗体都有相应的Prestige 抗原对照品,可在链接部分找到。
每种Prestige 抗体的检测方法如下:
每种Prestige 抗体的检测方法如下:
- 44种正常人体组织和20种最常见癌症组织的IHC组织阵列。
- 364个人重组蛋白片段的蛋白阵列。
Physical form
磷酸盐缓冲盐水溶液,pH 7.2,含有 40% 甘油和 0.02% 叠氮化钠。
Other Notes
对应抗原APREST73615
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
Still not finding the right product?
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
低风险生物材料
此项目有
Julien Record et al.
Blood, 126(13), 1527-1535 (2015-08-01)
Megakaryoblastic leukemia 1 (MKL1), also known as MAL or myocardin-related transcription factor A (MRTF-A), is a coactivator of serum response factor, which regulates transcription of actin and actin cytoskeleton-related genes. MKL1 is known to be important for megakaryocyte differentiation and
Michaela-Rosemarie Hermann et al.
Journal of cell science, 129(7), 1391-1403 (2016-02-14)
Integrin-mediated activation of small GTPases induces the polymerisation of G-actin into various actin structures and the release of the transcriptional co-activator MRTF from G-actin. Here we report that pan-integrin-null fibroblasts seeded on fibronectin and expressing β1- and/or αV-class integrin contained
Stefania Petrini et al.
Aging, 9(5), 1453-1469 (2017-06-01)
Nuclear integrity and mechanical stability of the nuclear envelope (NE) are conferred by the nuclear lamina, a meshwork of intermediate filaments composed of A- and B-type lamins, supporting the inner nuclear membrane and playing a pivotal role in chromatin organization
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| HPA030782-25UL | 04061842981960 |
| HPA030782-100UL | 04061833818688 |