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Merck
CN

HT501850

甲醛溶液,中性缓冲,10%

histological tissue fixative

别名:

甲醛

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关于此项目

UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47
MDL number:
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biological source

synthetic

Quality Level

concentration

10% formalin (approx. 4% formaldehyde)

color

colorless

pH

6.90-7.10

density

1.080 g/cm3

application(s)

hematology
histology

storage temp.

room temp

SMILES string

[O-]#[C+H2]

InChI

1S/CH2O/c1-2/h1H2

InChI key

WSFSSNUMVMOOMR-UHFFFAOYSA-N

General description

10% Neutral Buffered Formalin is the most used fixative throughout the world for light microscopy. Formalin solution is the commercially obtained solution containing 37% w/w (40% w/v) of formaldehyde in water. It requires a relatively short period of fixation. It is suitable for the long-term storage of tissue. Once properly fixed, the tissue should be able to withstand the subsequent stages of tissue processing or staining.

Application

10%的福尔马林中性缓冲溶液可用作血液病理学中免疫过氧化物酶法诊断应用的组织初步固定试剂。
常用的通用组织学固定剂。

Biochem/physiol Actions

Formaldehyde is both a non-coagulant and an additive fixative. Formalin fixation is thought to form cross links between the aldehydes and the proteins, creating a gel, thus retaining cellular constituents in their in vivo relationship. Formaldehyde is known to penetrate tissue quickly, but the fixation process may take a long time to form the various cross links with tissue proteins.

Features and Benefits

  • 10% NBF is well-suited for large throughput laboratories.
  • It requires a relatively short period of fixation.
  • It can be used for the long-term storage of tissue.

Physical form

中性缓冲的溶液


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pictograms

Health hazardExclamation mark

signalword

Danger

Hazard Classifications

Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 1B - Muta. 2 - Skin Sens. 1

wgk

WGK 3

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

185.0 °F

flash_point_c

85 °C

法规信息

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Diagnostic applications of an immunoperoxidase method in hematopathology.
Banks PM.
The Journal of Histochemistry and Cytochemistry, 27(8), 1192-1194 (1979)
Xiaozhen Liang et al.
PLoS pathogens, 7(9), e1002220-e1002220 (2011-09-21)
Human gammaherpesviruses are associated with the development of lymphoproliferative diseases and B cell lymphomas, particularly in immunosuppressed hosts. Understanding the molecular mechanisms by which human gammaherpesviruses cause disease is hampered by the lack of convenient small animal models to study
Caterina Nardella et al.
Science signaling, 2(55), ra2-ra2 (2009-01-30)
The mammalian target of rapamycin (mTOR) is a crucial effector in a complex signaling network commonly disrupted in cancer. mTOR exerts its multiple functions in the context of two different multiprotein complexes: mTOR complex 1 (mTORC1) and mTOR complex 2



全球贸易项目编号

货号GTIN
HT501850-200L04061838207722