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I0536

IWP-2

Name: IWP-2
Brand: SIGMA

≥98% (HPLC), powder, Wnt antagonist

别名:

N-（6-甲基-2-苯并噻唑基）-2-[（3,4,6,7-四氢-4-氧代-3-苯基噻吩并[3,2-d] 嘧啶-2-基）硫代]-乙酰胺

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关于此项目

经验公式（希尔记法）:

C₂₂H₁₈N₄O₂S₃

化学文摘社编号:

686770-61-6

分子量:

466.60

UNSPSC Code:

12352202

PubChem Substance ID:

329815312

NACRES:

NA.77

MDL number:

MFCD04457599

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

desiccated

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属性

产品名称

IWP-2, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

solubility

DMSO: 2 mg/mL, clear (warmed)

storage temp.

room temp

SMILES string

Cc1ccc2nc(NC(=O)CSC3=NC4=C(SCC4)C(=O)N3c5ccccc5)sc2c1

InChI

1S/C22H18N4O2S3/c1-13-7-8-15-17(11-13)31-21(23-15)25-18(27)12-30-22-24-16-9-10-29-19(16)20(28)26(22)14-5-3-2-4-6-14/h2-8,11H,9-10,12H2,1H3,(H,23,25,27)

InChI key

WRKPZSMRWPJJDH-UHFFFAOYSA-N

说明

Application

IWP-2已用于处理L-Wnt-3a和L-Wnt-5a细胞系以证明其抑制作用。它还作为Wnt信号抑制剂用于处理WT和Gja1Jrt/+基质、细胞，以确认Wnt/β-连环蛋白信号通路与Gja1Jrt/+成骨细胞的标志物表达增加无关。

Biochem/physiol Actions

IWP-2 是 Porcn 功能的失活剂；Wnt 生成抑制剂。

IWP-2 是 Porcn 功能的失活剂；Wnt 生成抑制剂。Wnt/β-catenin（“经典”）通路维持转录程序，使干细胞保持多能。Wnt/β-catenin 通路的过度激活导致疾病分期。IWP-2 抑制 Wnt 生成。IWP 可能通过直接抑制 Porcn 活性部位或通过调节 Porcn 调节器的功能而使 Porcn 功能失活。Porcn 是膜结合型 O-酰基转移酶 (MBOAT) 家族的一员，该家族为 Wnt 蛋白增加了一个棕榈酰基，该基团对其信号传导能力至关重要，是 Wnt 分泌所必需的。IWP-2 在再生医学和抗癌努力中都是有作用。

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存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

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Inhibition of Wnt signaling induces amyloidogenic processing of amyloid precursor protein and the production and aggregation of Amyloid-beta (A-beta) 42 peptides

Tapia-Rojas C, et al.

Journal of Neurochemistry, 139(6), 1175-1191 (2016)

Introduction of hsa-miR-103a and hsa-miR-1827 and hsa-miR-137 as new regulators of Wnt signaling pathway and their relation to colorectal carcinoma.

Ali Fasihi et al.

Journal of cellular biochemistry, 119(7), 5104-5117 (2017-08-18)

Wnt signaling is hyper-activated in most of human cancers including colorectal carcinoma (CRC). Therefore, the introduction of new regulators for Wnt pathway possesses promising diagnostic and therapeutic applications in cancer medicine. Bioinformatics analysis introduced hsa-miR-103a, hsa-miR-1827, and hsa-miR-137 as potential

Inhibition of Wnt signalling dose-dependently impairs the acquisition and expression of amphetamine-induced conditioned place preference.

Farhana Islam et al.

Behavioural brain research, 326, 217-225 (2017-03-13)

The mechanisms by which dopaminergic neurotransmission in the nucleus accumbens (NAc) is involved in incentive learning produced by rewarding stimuli remain unclear. Recently, Wnt signalling has been implicated in synaptic plasticity and learning and memory. Functional interactions between Wnt and

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