I0899
丙米嗪 盐酸盐
BioXtra, ≥99% (TLC)
别名:
10,11-二氢-N，N-二甲基-5H-苯并[b，f]氮杂卓-5-丙胺 盐酸盐, 5-[3-(二甲基氨基)丙基]-10,11-二氢-5H-苯并[b，f] 氮杂卓 盐酸盐
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关于此项目
经验公式（希尔记法）:
C19H24N2 · HCl
化学文摘社编号:
分子量:
316.87
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
204-030-7
MDL number:
product line
BioXtra
Quality Level
assay
≥99% (TLC)
form
powder
impurities
≤0.0005% Phosphorus (P), ≤0.1% Insoluble matter
ign. residue
≤0.1%
solubility
H2O: 50 mg/mL, colorless to faintly yellow
anion traces
sulfate (SO42-): ≤0.05%
cation traces
Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.005%, K: ≤0.005%, Mg: ≤0.0005%, NH4+: ≤0.05%, Na: ≤0.005%, Pb: ≤0.001%, Zn: ≤0.0005%
SMILES string
Cl[H].CN(C)CCCN1c2ccccc2CCc3ccccc13
InChI
1S/C19H24N2.ClH/c1-20(2)14-7-15-21-18-10-5-3-8-16(18)12-13-17-9-4-6-11-19(17)21;/h3-6,8-11H,7,12-15H2,1-2H3;1H
InChI key
XZZXIYZZBJDEEP-UHFFFAOYSA-N
Gene Information
human ... SLC6A2(6530), SLC6A4(6532)
Application
- 基于O端原始纳米晶掺硼金刚石电极的新颖、快速、可靠的电化学dsDNA生物传感器，适用于DNA相互作用研究。：该研究的特点是新型电化学dsDNA生物传感器有助于研究DNA与盐酸丙咪嗪的相互作用，从而加深我们对其基因毒性效应的了解，并为生物化学应用提供重要的启示（Augustín M et al., 2024）。
- 比较两种诱导驴体外射精的药理方案。：在这项比较研究中，盐酸丙咪嗪被用于药理学方案中，为兽医应用和动物生殖研究提供了重要见解（Khan FA et al., 2024）。
- 基于与对苯醌形成分子络合物的三环抗抑郁药可见分光光度测定方法的开发。：该出版物概述了分析盐酸丙咪嗪等三环抗抑郁药的新型分光光度法，为制药和临床研究中的定量分析提供了有效工具（Ciuca MD et al., 2023）。
Biochem/physiol Actions
三环类抗抑郁药；抑制 5-羟色胺和去甲肾上腺素转运蛋白；对多巴胺转运蛋白影响很小。
三环类抗抑郁药；抑制血清素和去甲肾上腺素转运蛋白的 Ki 值分别为 7.7 nM 和 67 nM。对多巴胺转运蛋白影响很小（Ki = 25 μM）。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 2 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
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Ute Krügel et al.
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Pro-inflammatory cytokines such as tumour necrosis factor-alpha (TNF-α) have repeatedly been shown to play a pivotal role in the pathophysiology of depression. Therefore, we tested the possible antidepressant-like effect of the anti-TNF-α drug etanercept in an animal model of chronic
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I0899-5G | 04061833847305 |
| I0899-25G | 04061833620991 |