biological source
human
Quality Level
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
lyophilized powder
mol wt
monomer 8.9 kDa ((77 aa))
packaging
pkg of 10 μg
technique(s)
cell culture | mammalian: suitable
impurities
≤1 EU/μg (LAL test)
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IL8(3576)
Application
白细胞介素-8 (IL-8) 用于：
- 测量中性粒细胞化学毒性
- 脑膜上皮细胞摄取凋亡细胞的研究
- IL-8 对人脐静脉内皮细胞表达和分泌尿促皮素-1 的影响
Biochem/physiol Actions
白细胞介素-8 (IL-8) 以往称为单核细胞衍生的中性粒细胞趋化因子，属于趋化因子 αC-X-C 家族。IL-8 的成熟形式有 4 个半胱氨酸残基，趋化因子家族的其他成员也是如此，前两个半胱氨酸残基被谷氨酰胺分开。成熟人 IL-8 由 72 个氨基酸组成，分子量为 8.4 kDa。IL-8 在体外 对 T 细胞、嗜碱性粒细胞表现出趋化活性 ，通过酶包括髓过氧化物酶、α-甘露糖苷酶和 β-葡萄糖醛酸酶。IL-8 是一种血管生成因子。
白细胞介素-8 (IL-8) 原称单核细胞源性中性粒细胞趋化因子。属于趋化因子 αC-X-C 家族。与该家族的其他成员一样，IL-8 的成熟形式有 4 个半胱氨酸残基，前 2 个半胱氨酸残基被谷氨酰胺分开。IL-8 在体外 对 T 细胞、中性粒细胞和嗜碱粒细胞具有趋化活性 。IL-8 基因突变可增加急性胰腺炎的发病风险。
Physical form
从 0.2 μm 冻干m 过滤溶液，无添加剂。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
L M Nemec et al.
Journal of dairy science, 95(8), 4568-4577 (2012-07-24)
The aim of this study was to compare effects of inorganic sulfate versus chelated forms of supplemental Cu, Mn, and Zn on milk production, plasma and milk mineral concentrations, neutrophil activity, and antibody titer response to a model vaccination. Holstein
Lavínia E Borges et al.
Peptides, 74, 64-69 (2015-11-10)
Urocortin 1 (Ucn1) is a 40-amino-acid peptide that has vasodilatory activity and displays immunomodulatory and antioxidant properties. Maternal and cord plasma Ucn1 levels are increased in preeclampsia and preterm labor, but the mechanisms of such increase are poorly known. Thus
M V White et al.
Immunology letters, 22(2), 151-154 (1989-08-01)
Basophils from five of six human donors released histamine in response to neutrophil attractant/activation protein-1 (NAP-1). Histamine release by this protein was concentration-dependent over the range of 3 x 10(-7) M to 4 x 10(-6) M. At 4 x 10(-6)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I1645-10UG | 04061833847947 |