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I2765

鹅膏氨酸

~95% (TLC), solid, neurotoxin

别名:

α-氨基-3-羟基-5-异噁唑乙酸

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关于此项目

经验公式（希尔记法）:
C5H6N2O4
化学文摘社编号:
2552-55-8
分子量:
158.11
UNSPSC Code:
12352209
PubChem Substance ID:
24277994
NACRES:
NA.32
MDL number:
MFCD00069294
Assay:
~95%
Form:
solid
Quality level:
100
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产品名称

鹅膏氨酸, ~95%, solid

assay

~95%

Quality Level

100

form

solid

color

white

solubility

H2O: 1 mg/mL, clear, colorless (with sonication), 0.1 M NaOH: 10.7 mg/mL, 0.1 M HCl: 4.7 mg/mL

SMILES string

NC(C(O)=O)C1=CC(=O)NO1

InChI

1S/C5H6N2O4/c6-4(5(9)10)2-1-3(8)7-11-2/h1,4H,6H2,(H,7,8)(H,9,10)

InChI key

IRJCBFDCFXCWGO-UHFFFAOYSA-N

Gene Information

rat ... Grm1(24414), Grm2(24415)

Application

鹅膏蕈氨酸作为神经毒素用于大鼠。也可用于诱导猴大脑皮层M1神经元发生原发永久性病变。
鹅膏蕈氨酸被用于成年雄性斑胸草雀 ( Taeniopygia guttata ) 手术，以研究逆转增强剂诱导的发声变化。

Biochem/physiol Actions

鹅膏蕈氨酸是谷氨酸类似物。参与兴奋细胞体，破坏丘脑网状核（NRT）。它能诱导大量钙离子流入，导致神经元损伤。由于其具有兴奋性毒性功能，鹅膏蕈氨酸用于诱导产生神经退行性变。
对NMDA谷氨酸受体优先选择的非选择性激动剂;神经毒素。
对NMDA谷氨酸受体优先选择的非选择性激动剂;神经毒素。神经兴奋性氨基酸最初分离自鹅膏菌种。

Disclaimer

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

高风险级别生物产品--毒素类产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BGBC2055V
BGBC1399V
BGBC1368V
028K38091
028K3809

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全球贸易项目编号

货号GTIN
I2765-10MG04061833007518
I2765-1MG04061833848654
I2765-25MG04061833007525
I2765-5MG04061833848661