I4131
IgG 来源于大鼠血清
reagent grade, ≥95% (SDS-PAGE), essentially salt-free, lyophilized powder
别名:
大鼠 IgG
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关于此项目
Conjugate:
unconjugated
Species reactivity:
-
Application:
—
Citations:
38
conjugate
unconjugated
Quality Level
grade
reagent grade
assay
≥95% (SDS-PAGE)
form
essentially salt-free, lyophilized powder
storage temp.
2-8°C
target post-translational modification
unmodified
General description
IgG 抗体亚型是免疫系统中含量最高的血清免疫球蛋白。由B细胞分泌，存在于血液和细胞外液中，免疫球蛋白有两条重链（H）和两条轻链（L），通过二硫键连接。 每条轻链含一个N-末端可变区和一个C-末端恒定区。重链有一个N-末端可变区和三个或四个（CH1-CH4）C-末端恒定区。IgG 的四种类型分别为IgG1、IgG2、IgG3和IgG4。IgG抗体提供保护作用，防止细菌、真菌和病毒引起的感染。母体IgG通过胎盘传递给胎儿，对新生儿抵抗感染的免疫防御能力至关重要。大鼠IgG 由分级分离和离子交换层析从混合的正常大鼠血清中纯化得到。
Application
大鼠血清IgG用于：
- 免疫标记
- 流式细胞术
- 酶联免疫吸附试验
- 作为对照品，用于中性粒细胞耗竭试验
Biochem/physiol Actions
IgG抗体具有巨大的治疗潜力，其可结晶片段（Fc）区域有助于研发治疗性抗体。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
此项目有
实验方案
使用RIP试剂盒进行哺乳动物细胞Ago抗体-RNA免疫沉淀的实验方案和流程
Procedure and protocol for Anti Ago-RNA Immunoprecipitation from mammalian cells using the RIP kit
商品
Sigma Imprint RNA 免疫沉淀试剂盒用于从 HeLa 细胞中共纯化人 argonaute 2 (Ago2) 相关 RNA。MicroRNA通过Mysticq 试剂进行逆转录和定量。
Sigma’s Imprint RNA Immunoprecipitation Kit was used to copurify human argonaute 2 (Ago2)-associated RNAs from HeLa cells. MicroRNAs reverse transcribed and quantitating using Mysticq reagents.
Catharina D Commerford et al.
Cell reports, 25(13), 3554-3563 (2018-12-28)
Enlargement of the lymphatic vascular network in tumor-draining lymph nodes (LNs) often precedes LN metastasis, likely providing a lymphovascular niche for tumor cells. We investigated morphological and molecular changes associated with the lymphatic remodeling process, using the 4T1 breast cancer
Comparative study of two protocols for quantitative image-analysis of serotonin transporter clustering in lymphocytes, a putative biomarker of therapeutic efficacy in major depression
Romay-Tallon R, et al.
Biomarker research, 5(1), 27-27 (2017)
Anuj Sehgal et al.
Nature communications, 9(1), 1272-1272 (2018-03-30)
Colony-stimulating factor 1 (CSF1) controls the growth and differentiation of macrophages.CSF1R signaling has been implicated in the maintenance of the intestinal stem cell niche and differentiation of Paneth cells, but evidence of expression of CSF1R within the crypt is equivocal.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I4131-10MG | 04061833856628 |
| I4131-50MG | 04061833856635 |
| I4131-100MG | 04061833856611 |