biological source
human
Quality Level
recombinant
expressed in NSO cells
assay
≥95% (SDS-PAGE)
form
lyophilized powder
mol wt
α-chain ~120 & 150 kDa, β subunit ~46 & 50 kDa
packaging
pkg of 50 μg
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... IGF1R(3480)
General description
IGF1R (insulin-like growth factor I) is a receptor tyrosine kinase. The gene is mapped to human chromosome 15q26. It is expressed in various solid tumors as well as hematologic malignancies.
Application
Insulin-like growth factor-I receptor human has been used to study the binding constants of estradiol to insulin, insulin receptors and insulin-like peptides.
Biochem/physiol Actions
Binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
IGF-I receptor, a tyrosine kinase receptor with signal transduction pathways, is comprised of two α and two β subunits. IGF-I receptor binds IGF-I with high affinity, IGF-II with lower affinity, and insulin with weak affinity.
Physical form
Lyophilized from a 0.2 μm solution in phosphate buffered saline.
Analysis Note
As a result of glycosylation in SDS-PAGE under reducing conditions, the recombinant α subunit migrates as a doublet of ~120 kDa and 150 kDa and the β subunit migrates as doublet of ~46 kDa and 50 kDa.
The biological activity is measured by its ability to bind human IGF-I in a functional ELISA assay.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Sandra Heskamp et al.
PloS one, 10(2), e0117745-e0117745 (2015-02-14)
The insulin-like growth factor 1 receptor (IGF-1R) may be involved in the development of resistance against conventional cancer treatment. The aim of this study was to assess whether IGF-1R expression of breast tumors changes during neoadjuvant therapy and to study
Xin Huang et al.
PloS one, 10(7), e0133152-e0133152 (2015-07-15)
Patients with metastatic or recurrent and refractory sarcomas have a dismal prognosis. Therefore, new targeted therapies are urgently needed. This study was designed to evaluate chimeric antigen receptor (CAR) T cells targeting the type I insulin-like growth factor receptor (IGF1R)
Jin-Ho Choi et al.
The Journal of clinical endocrinology and metabolism, 96(1), E130-E134 (2010-10-22)
Mutations in the IGF1R gene result in intrauterine growth retardation and postnatal growth failure. The objective of this study was to describe the clinical features of subjects with a mutation in the IGF1R gene and to evaluate the molecular and
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I4657-50UG | 04061833856956 |