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I4883

布洛芬

≥98% (GC), powder, COX inhibitor

别名:

2-(4-异丁苯)丙酸, Motrin, Rebugen, 布洛芬, α-甲基-4-(异丁基)苯乙酸, (±)-2-(4-异丁基苯基)丙酸

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关于此项目

经验公式（希尔记法）:
C13H18O2
化学文摘社编号:
15687-27-1
分子量:
206.28
NACRES:
NA.77
PubChem Substance ID:
24277715
UNSPSC Code:
12352200
EC Number:
239-784-6
MDL number:
MFCD00010393
Assay:
≥98% (GC)
Form:
powder
Quality level:
100
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产品名称

布洛芬, ≥98% (GC)

biological source

synthetic (organic)

Quality Level

100

assay

≥98% (GC)

form

powder

mp

77-78  °C

solubility

ethanol: 50 mg/mL, clear, colorless to faintly yellow

SMILES string

CC(C)Cc1ccc(cc1)C(C)C(O)=O

InChI

1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)

InChI key

HEFNNWSXXWATRW-UHFFFAOYSA-N

Gene Information

human ... ALB(213), ALOX5(240), CYP1A2(1544), CYP2C9(1559), IL8RA(3577), PTGS1(5742), PTGS2(5743)
mouse ... Alox5(11689)
rat ... Alox5(25290), Ptgs1(24693)

General description

布洛芬是一种非类固醇抗炎药(NSAID)，常用来止痛、消炎、退烧。它会抑制多种抗高血压药物作用，包括β肾上腺素能阻滞剂、血管紧张素转换酶抑制剂、血管紧张素受体阻滞剂和利尿剂。布洛芬在脑脊液中以未结合状态存在，在关节炎患者中会积聚在炎症关节的滑膜液中。

Application

布洛芬用于：
  • 研究其对新生儿肺发育的血管和肺影响
  • 研究其对人胆管癌细胞株凋亡、增殖和组织学变化的影响
  • 在萜类治疗性低共溶体系(therapeutic deep eutectic system)制备中，研究其物化、抗菌和抗癌特性。

Biochem/physiol Actions

环加氧酶 (COX) 抑制剂，对 COX-1 的抑制活性大于对 COX-2 的抑制活性。

Other Notes

2024年CiteAb奖——成功的帕金森研究供应商(2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research)

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pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCL5572
SLCH8939
SLCG1870
SLCD1404
SLBX6584

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Discover Bioactive Small Molecules for Lipid Signaling Research

Discover Bioactive Small Molecules for Lipid Signaling Research

Jennifer S Chen et al.
bioRxiv : the preprint server for biology (2020-10-01)
Identifying drugs that regulate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and its symptoms has been a pressing area of investigation during the coronavirus disease 2019 (COVID-19) pandemic. Nonsteroidal anti-inflammatory drugs (NSAIDs), which are frequently used for the relief
Mateusz P Czub et al.
Journal of medicinal chemistry, 63(13), 6847-6862 (2020-05-30)
Every day, hundreds of millions of people worldwide take nonsteroidal anti-inflammatory drugs (NSAIDs), often in conjunction with multiple other medications. In the bloodstream, NSAIDs are mostly bound to serum albumin (SA). We report the crystal structures of equine serum albumin
Tzu-Feng Wang et al.
Cells, 11(3) (2022-02-16)
Parkinson's disease (PD) is an age-related neurodegenerative disease caused by a selective loss of dopaminergic (DA) neurons in the substantia nigra (SN). Microglial activation is implicated in the pathogenesis of PD. This study aimed to characterize the role of microglial
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货号GTIN
I4883-10G04061835557325
I4883-1G04061833856994
I4883-5G04061833857007