I9910
Ibutilide hemifumarate salt
≥98% (HPLC), Class III antiarrhythmic agent, solid
别名:
(±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]-methanesulfonamide hemifumarate salt, Corvert
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关于此项目
经验公式（希尔记法）:
C20H36N2O3S · 0.5C4H4O4
化学文摘社编号:
分子量:
442.61
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Ibutilide hemifumarate salt, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
solid
color
off-white to tan
solubility
H2O: >20 mg/mL
storage temp.
room temp
SMILES string
OC(=O)\C=C\C(O)=O.CCCCCCCN(CC)CCCC(O)c1ccc(NS(C)(=O)=O)cc1.CCCCCCCN(CC)CCCC(O)c2ccc(NS(C)(=O)=O)cc2
InChI
1S/2C20H36N2O3S.C4H4O4/c2*1-4-6-7-8-9-16-22(5-2)17-10-11-20(23)18-12-14-19(15-13-18)21-26(3,24)25;5-3(6)1-2-4(7)8/h2*12-15,20-21,23H,4-11,16-17H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;;2-1+
InChI key
PCIOHQNIRPWFMV-WXXKFALUSA-N
Gene Information
human ... KCNH2(3757)
Biochem/physiol Actions
Ibutilide hemifumarate salt is considered a new generation "pure" Class III antiarrhythmic agent.
Ibutilide hemifumarate salt is considered a new generation "pure" Class III antiarrhythmic agent. Ibutilide binds to and alters the activity of hERG potassium channels, delayed inward rectifier potassium (IKr) channels and L-type (dihydropyridine sensitive) calcium channels.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Atrial fibrillation: AVRO--were the results a surprise?
Soraya M Samii et al.
Nature reviews. Cardiology, 8(4), 188-190 (2011-03-03)
Mohamed Boulaksil et al.
Circulation. Arrhythmia and electrophysiology, 4(4), 566-576 (2011-05-31)
The electrically remodeled canine heart after chronic AV block (CAVB) has a high susceptibility for drug-induced torsade de pointes (TdP) arrhythmias. Although focal mechanisms have been considered for initiation, there is still controversy about whether reentry is the dominant mechanism
Jian-ling Sun et al.
Zhonghua xin xue guan bing za zhi, 37(10), 920-924 (2010-02-09)
To observe the electrophysiological effects of ibutilide on canine and to explore the potential mechanisms of ibutilide on terminating atrial flutter. Eighteen mongrel dogs were anesthetized and intubated. The heart was exposed through thoracotomy for electrodes implantation. The electrophysiologic variables
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| I9910-10MG | 04061832574691 |
| I9910-50MG | 04061832574707 |