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K1377

卡那霉素 硫酸酯 来源于卡那霉素链霉菌

powder, BioReagent, suitable for cell culture, suitable for plant cell culture

别名:

卡那霉素 A, 卡那霉素碱 硫酸盐

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关于此项目

经验公式（希尔记法）:
C18H36N4O11 · H2O4S
化学文摘社编号:
25389-94-0
分子量:
582.58
NACRES:
NA.76
PubChem Substance ID:
24896204
UNSPSC Code:
51281654
EC Number:
246-933-9
MDL number:
MFCD00070253
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biological source

Streptomyces kanamyceticus

Quality Level

200

product line

BioReagent

form

powder

potency

≥750 μg per mg (dry basis)

technique(s)

cell culture | mammalian: suitable, cell culture | plant: suitable

color

white to off-white

solubility

H2O: 10-50 mg/mL (As a stock solution. Stock solutions should be stored at 2-8°C. Stable at 37°C for 5 days.)

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria, mycobacteria, mycoplasma

application(s)

agriculture

mode of action

protein synthesis | interferes

SMILES string

OS(O)(=O)=O.NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H](CO)[C@@H](O)[C@H](N)[C@H]3O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C18H36N4O11.H2O4S/c19-2-6-10(25)12(27)13(28)18(30-6)33-16-5(21)1-4(20)15(14(16)29)32-17-11(26)8(22)9(24)7(3-23)31-17;1-5(2,3)4/h4-18,23-29H,1-3,19-22H2;(H2,1,2,3,4)/t4-,5+,6-,7-,8+,9-,10-,11-,12+,13-,14-,15+,16-,17-,18-;/m1./s1

InChI key

OOYGSFOGFJDDHP-KMCOLRRFSA-N

General description

Chemical structure: aminoglycoside
在生物技术中用于抑制蛋白质合成。建议以 100mg/L 的量用于细胞培养应用。

Application

Kanamycin sulfate from Streptomyces kanamyceticus has been used in tissue culture media.

Biochem/physiol Actions

作用机制：该产品通过与70S核糖体亚基结合，抑制易位并引起错误编码而起作用。

耐药机制：氨基糖苷类修饰酶（包括乙酰转移酶、磷酸转移酶、核苷酸转移酶）可以改变这种抗生素，阻止其与核糖体相互作用。

抗菌谱：硫酸卡那霉素对革兰氏阴性和革兰氏阳性菌以及支原体有效。

Preparation Note

Kanamycin sulfate is soluble in water at 50 mg/mL, yielding a clear solution. It is practically insoluble in alcohol, acetone, chloroform, ether and ethyl acetate. A 1% solution in water has a pH of 6.5 to 8.5. Sterile solutions can be prepared by a sterile filtration, through a .2μm filter.

Disclaimer

Solutions are stable at 37°C for approximately 5 days. Aqueous stock solutions can be stored at 2-8°C for long term storage.

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 2

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCK0906
SLCH7600
SLCG0261
SLCC5013
WXBC9915V

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全球贸易项目编号

货号GTIN
K1377-25G04061835521890
K1377-1G04061835516117
K1377-5G04061835545889