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关于此项目
经验公式(希尔记法):
C19H19NOS · C4H4O4
化学文摘社编号:
分子量:
425.50
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
252-100-0
MDL number:
Form:
powder
Quality level:
产品名称
酮替芬 富马酸盐,
form
powder
Quality Level
originator
Novartis
SMILES string
OC(=O)\C=C\C(O)=O.CN1CCC(\CC1)=C2/c3ccccc3CC(=O)c4sccc24
InChI
1S/C19H19NOS.C4H4O4/c1-20-9-6-13(7-10-20)18-15-5-3-2-4-14(15)12-17(21)19-16(18)8-11-22-19;5-3(6)1-2-4(7)8/h2-5,8,11H,6-7,9-10,12H2,1H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
InChI key
YNQQEYBLVYAWNX-WLHGVMLRSA-N
Gene Information
human ... HRH1(3269), PDE7B(27115)
General description
富马酸酮替芬盐是一种抗组胺药。
Application
富马酸酮替芬盐已被用于:肥大细胞产物拮抗作用,作为 β-氨基己糖苷酶释放测试的阳性对照,作为肥大细胞稳定剂添加到饮用水中用于治疗怀孕母兽
Biochem/physiol Actions
富马酸酮替芬通过阻断组胺H1受体而在阻止组胺的释放中起关键作用。它会干扰肥大细胞释放组胺、血清素和其他炎症介质。它具有抗过敏活性、消炎作用(包括使肥大细胞稳定)。它已被广泛用于眼部过敏性结膜炎。
H1 组胺受体拮抗剂。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Anthony Soluri et al.
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Investigation into the mechanism of action of Moringa oleifera for its anti-asthmatic activity
Mehta A and Agrawal B
Oriental Pharmacy and Experimental Medicine, 8(1), 24-31 (2008)
Inhibitory effect of various Tunisian olive oils on chemical mediator release and cytokine production by basophilic cells
Yamada P, et al.
Journal of Ethnopharmacology, 116(2), 279-287 (2008)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| K2628-100MG | 04061833868324 |
| K2628-1G | 04061833868331 |
