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L0520

乳铁蛋白 来源于人奶

≥85% (SDS-PAGE), lyophilized powder

别名:

Growth-inhibiting protein 12, Lactotransferrin, Talalactoferrin

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关于此项目

化学文摘社编号:
936541-36-5
UNSPSC Code:
12352202
NACRES:
NA.61
MDL number:
MFCD00164307
Form:
lyophilized powder
Assay:
≥85% (SDS-PAGE)
Biological source:
human milk
Mol wt:
82.4 kDa
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biological source

human milk

Quality Level

200

assay

≥85% (SDS-PAGE)

form

lyophilized powder

mol wt

82.4 kDa

composition

Protein, ≥90% biuret

technique(s)

microbiological culture: suitable

solubility

phosphate buffer: 1 mg/mL, clear to slightly hazy (0.01 M phosphate buffer, 0.0027 M potassium chloride and 0.137 M sodium chloride, pH 7.4, at 25 °C)

UniProt accession no.

P02788

storage temp.

2-8°C

SMILES string

N([C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)O)C(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CC(=O)N)C)CC(=O)O

InChI

1S/C35H53N9O12/c1-16(2)27(43-33(53)23(14-26(47)48)41-25(46)15-38-29(49)18(5)39-31(51)21(36)13-24(37)45)34(54)40-19(6)30(50)42-22(12-20-10-8-7-9-11-20)32(52)44-28(17(3)4)35(55)56/h7-11,16-19,21-23,27-28H,12-15,36H2,1-6H3,(H2,37,45)(H,38,49)(H,39,51)(H,40,54)(H,41,46)(H,42,50)(H,43,53)(H,44,52)(H,47,48)(H,55,56)/t18-,19-,21-,22-,23-,27-,28-/m0/s1

InChI key

QCBUWCQOKPLTDZ-PKRULZLPSA-N

Gene Information

human ... LTF(4057)

Application

乳铁蛋白用于在铁限制培养基中生长变形链球菌。 它用于测试乳铁蛋白是否在体外阻止上皮细胞粘附。

Biochem/physiol Actions

乳铁蛋白是一种铁结合蛋白。在结构上与血浆铁转运蛋白转铁蛋白相似；但是乳铁蛋白对铁的亲和力要高得多（250 倍）。在初乳中含量非常丰富，少量也可见于泪液、唾液、粘液分泌物和中性粒细胞的次级颗粒中。由粘膜上皮和中性粒细胞组成，在炎症刺激下由这些细胞释放。细菌的生长被其隔离铁的能力所抑制，也通过其 N 端与脂多糖结合使细菌细胞壁通透性增加。乳铁蛋白可以通过与病毒包膜蛋白紧密结合来抑制病毒感染。它通过阻断结合域阻止了细胞与病毒的融合。乳铁蛋白似乎部分通过刺激中性粒细胞激活剂白细胞介素-8 的释放来激活宿主防御系统。还可能参与抗体和白细胞介素合成、淋巴细胞增殖和补体激活。

Preparation Note

色谱纯化产品。

Analysis Note

包含铁，有关批次特异性信息，请参见检验报告。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

高风险级别生物产品--人源产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCJ6311
SLCG3356
SLBW5976
SLBR9569V
SLBN0081V

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Grace A. Spatafora, Meagan W. Moore
Methods in Cell Science : An Official Journal of the Society for In Vitro Biology, 20, 217-221 (1998)
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Inflammation research : official journal of the European Histamine Research Society ... [et al.], 61(11), 1247-1255 (2012-07-20)
The aim of this study was to assess the utility of lactoferrin (LF), a natural immunomodulator, to restrain allergen-induced pleurisy in mice. BALB/c female mice, 8- to 10-week old, weighing 24 g on average, were used. Mice were immunized intraperitoneally
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L0520-100MG04061833948804
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