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L1167

拉坦前列素

≥98% (HPLC)

别名:

异丙基 (5Z,9α,11α,15R)-9,11,15-三羟基-17-苯基-18,19,20-三硝基苯-5-烯-1-酸酯, 异丙基 ( Z )-7-[(1 R ,2 R ,3 R ,5 S )-3,5-二羟基-2-[(3 R )-3-羟基-5-苯戊基] 环戊基] 庚烯-5-酸酯, 适利达

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关于此项目

经验公式（希尔记法）:
C26H40O5
化学文摘社编号:
130209-82-4
分子量:
432.59
NACRES:
NA.77
PubChem Substance ID:
24724523
UNSPSC Code:
12352200
MDL number:
MFCD00216074
Assay:
≥98% (HPLC)
Form:
oil
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

oil

color

colorless to yellow

solubility

DMSO: freely soluble, methanol: soluble

originator

Johnson & Johnson

shipped in

wet ice

storage temp.

−20°C

SMILES string

CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCc2ccccc2

InChI

1S/C26H40O5/c1-19(2)31-26(30)13-9-4-3-8-12-22-23(25(29)18-24(22)28)17-16-21(27)15-14-20-10-6-5-7-11-20/h3,5-8,10-11,19,21-25,27-29H,4,9,12-18H2,1-2H3/b8-3-/t21-,22+,23+,24-,25+/m0/s1

InChI key

GGXICVAJURFBLW-CEYXHVGTSA-N

Gene Information

human ... PTGFR(5737)

Application

拉坦前列素已被用于：
  • 制备包含姜黄素纳米颗粒（CUR-NP）的热敏水凝胶，以确定其在氧化应激下对人小梁网（TM）细胞的治疗作用。
  • 作为酯类前药用于研究其对小鼠鼠眼表面的作用
  • 制备热敏水凝胶用于研究其对控制高眼压症的作用。

Biochem/physiol Actions

拉坦前列素是一种强效、选择性前列腺素F2 α类似物受体激动剂。它在角膜中被酯酶水解为拉坦前列素酸的生物活性形式。拉坦前列素在降低眼内压（IOP）方面起一定作用，因此它具有治疗青光眼的疗效。

Features and Benefits

《受体分类和信号转导》手册的 前列腺素类受体 页面有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由 Johnson & Johnson 开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。

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pictograms

Health hazard
GHS08

signalword

Warning

hcodes

H361d

Hazard Classifications

Repr. 2

存储类别

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
022M4708V
080M4715
106K47064
106K47063
106K47062

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全球贸易项目编号

货号GTIN
L1167-5MG04061832785578
L1167-1MG04061826675618