L7035
Clasto-乳胞素 β-内酯
≥95% (HPLC), irreversible proteasome inhibitor, film
别名:
(1R,4R,5S)-1-[(1S)-1-羟基-2-甲基丙基]-4-甲基-6-氧杂-2-氮杂双环[3.2.0]庚烷-3,7-二酮, Omuralide
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关于此项目
经验公式（希尔记法）:
C10H15NO4
化学文摘社编号:
分子量:
213.23
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Clasto-乳胞素 β-内酯,
assay
≥95% (HPLC)
Quality Level
form
film
solubility
DMSO: soluble 25 mg/mL
storage temp.
−20°C
SMILES string
[H][C@@]12OC(=O)[C@@]1(NC(=O)[C@@H]2C)[C@@H](O)C(C)C
InChI
1S/C10H15NO4/c1-4(2)6(12)10-7(15-9(10)14)5(3)8(13)11-10/h4-7,12H,1-3H3,(H,11,13)/t5-,6+,7+,10-/m1/s1
InChI key
FWPWHHUJACGNMZ-NBBQQVJHSA-N
Application
Clasto-乳胞素 β-内酯用作蛋白酶体抑制剂。
Clasto-乳胞素β-内酯已用作蛋白降解抑制剂以检测其对小鼠记忆改善的作用。它还用作人卵巢上皮(HOSE)细胞和树突状细胞(DC)的蛋白酶体抑制剂。
Biochem/physiol Actions
Clasto-乳胞素β-内酯(cLβL)由乳胞素(Lactacystin)合成。它具有细胞可透过性。cLβL可作用于蛋白酶体β -亚基X的N端苏氨酸。还可通过作用于β -型亚基的N-苏氨酸残基，抑制嗜盐古菌Haloferax volcanii的20S蛋白酶体活性。
细胞渗透性和不可逆蛋白酶体抑制剂。乳胞素作为染色体断裂-乳胞素 β 的前体-内酯。
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signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
Florian Vogel et al.
Traffic (Copenhagen, Denmark), 8(9), 1205-1214 (2007-07-17)
Intracellular trafficking of viral movement proteins (MPs) in plants has mainly been studied using Tobacco mosaic virus MP30 (TMV MP30) as a model system. Because of the limitations of TMV MP30 expression in Arabidopsis thaliana, these studies have mostly been
A Craiu et al.
The Journal of biological chemistry, 272(20), 13437-13445 (1997-05-16)
The antibiotic lactacystin was reported to covalently modify beta-subunit X of the mammalian 20 S proteasome and inhibit several of its peptidase activities. However, we demonstrate that [3H]lactacystin treatment modifies all the proteasome's catalytic beta-subunits. Lactacystin and its more potent
A K Ho et al.
Endocrinology, 148(2), 743-751 (2006-11-04)
In this study, we investigated the role of two inducible repressor proteins, inducible cAMP early repressor (ICER) and Fos-related antigen 2 (Fra-2) in the adrenergic induction of MAPK phosphatase-1 (MKP-1) as compared with their roles in the induction of arylalkylamine-N-acetyltransferase
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L7035-.1MG | 04061833965344 |