产品名称
利多卡因, powder
form
powder
Quality Level
SMILES string
CCN(CC)CC(=O)Nc1c(C)cccc1C
InChI
1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)
InChI key
NNJVILVZKWQKPM-UHFFFAOYSA-N
Gene Information
human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1a(25122)
General description
Lidocaine is a local anesthetic and an effective antiarrhythmia agent. It occurs as solutions of crystalline colorless solid for injections, that has a short half-life within plasma.
Application
Lidocaine may be used for drug testing and for voltage clamp experiments.
Biochem/physiol Actions
Lidocaine, a neuroprotective agent, mediates blockage of sodium (Na+) channels. It prevents the influx of sodium ions leading to depolarization of sodium channels and metabolically inactivated in liver. Lidocaine has positive effect on cerebral ischemia. It is also used in the treatment of ventricular tachycardia. Lidocaine is an efficient anesthetic agent in ophthalmic surgeries as it is highly potent and has good tissue penetrability.
Na+通道阻滞剂;IB类抗心律失常药。
Na+通道阻滞剂;在肠胃外给药后可迅速被吸收的IB类抗心律失常药。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy (2008)
Cytotoxicity of lidocaine to human corneal endothelial cells in vitro
Yu HZ, et al.
Basic and Clinical Pharmacology and Toxicology, 114(4), 352-359 (2014)
A microfluidic gradient maker for toxicity testing of bupivacaine and lidocaine
Tirella A, et al.
Toxicology in vitro, 22(8), 1957-1964 (2008)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L7757-25G | 04061835374779 |
| L7757-100G | 04061833965665 |
