L9908
LY-294,002 盐酸盐
from microbial (Staphylococcus roseus), ≥98% (HPLC), solid, PI3K inhibitor
别名:
2-(4-吗啉基)-8-苯基-1(4H)-苯并吡喃-4-酮 盐酸盐
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关于此项目
经验公式（希尔记法）:
C19H17NO3 · HCl
化学文摘社编号:
分子量:
343.80
UNSPSC Code:
12352207
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
LY-294,002 盐酸盐, solid, ≥98% (HPLC)
biological source
microbial (Staphylococcus roseus)
Quality Level
assay
≥98% (HPLC)
form
solid
color
white to off-white
solubility
DMSO: >5 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
O=C1C=C(Oc2c1cccc2-c3ccccc3)N4CCOCC4
InChI
1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChI key
CZQHHVNHHHRRDU-UHFFFAOYSA-N
General description
LY-294,002盐酸盐是类黄酮化合物槲皮素的衍生物，可引发对磷酸肌醇3-激酶（PI3K）的更高抑制。LY-294,002可抑制巨噬细胞的核因子κB信号传导。它可以提高自噬体蛋白LC3的表达，并促进胃癌 和鼻咽癌细胞的凋亡。LY-294,002可调节动作电位复极化并改善肌细胞收缩性。
Application
LY-294,002盐酸盐已被用于抑制：
- 人肺癌细胞中的磷酸肌醇3-激酶（PI3K）
- 间充质干细胞（MSCs）的自噬。
- 成纤维细胞 心肌细胞中的丝氨酸/苏氨酸特异性蛋白激酶（AKT）信号传导。
Biochem/physiol Actions
磷脂酰肌醇3-激酶的特异性细胞渗透性抑制剂。
Features and Benefits
该化合物是环核苷酸和激酶磷酸酶生物学研究的特色产品。发现更多环核苷酸和激酶磷酸酶生物学特色产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| L9908-5MG | 04061833967072 |
| L9908-1MG | 04061833967065 |