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M149

甲硫替平 甲磺酸盐

≥98% (HPLC), solid

别名:

1-[10，11-二氢-8-（甲硫基）二苯并[b，f]硫平-10-基]-4-甲基哌嗪 甲磺酸盐, 甲替平 甲磺酸盐

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关于此项目

线性分子式:
C20H24N2S2 · CH3SO3H
化学文摘社编号:
74611-28-2
分子量:
452.65
NACRES:
NA.77
PubChem Substance ID:
24278104
UNSPSC Code:
12352200
MDL number:
MFCD00153831
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
desiccated
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Quality Level

100

assay

≥98% (HPLC)

form

solid

storage condition

desiccated

color

white

solubility

H2O: 13 mg/mL

SMILES string

CS(O)(=O)=O.CSc1ccc2Sc3ccccc3CC(N4CCN(C)CC4)c2c1

InChI

1S/C20H24N2S2.CH4O3S/c1-21-9-11-22(12-10-21)18-13-15-5-3-4-6-19(15)24-20-8-7-16(23-2)14-17(18)20;1-5(2,3)4/h3-8,14,18H,9-13H2,1-2H3;1H3,(H,2,3,4)

InChI key

CZMDZGZYKOGLJY-UHFFFAOYSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR6(3362), HTR7(3363)

General description

甲硫替平属于一类新的二苯并噻吩。甲硫替平具有精神抑制活性。

Application

甲硫替平甲磺酸盐已用于探索循环细胞与生态位之间的关系。它也已用于5-羟色胺（5-HT）和拮抗剂体内生物测定以及体内拮抗剂和脂多糖刺激。

Biochem/physiol Actions

甲硫替平甲磺酸盐是一种5-HT1、5-HT6、5-HT75-羟色胺受体拮抗剂，可阻断5-羟色胺自身受体。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
095M4737V
114M4719V
123M4719V
109K4612
106K47053

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P Schoeffter et al.
British journal of pharmacology, 117(6), 993-994 (1996-03-01)
Human uterine artery smooth muscle cells in culture were shown to express constitutively both 5-ht7 receptor mRNA and 5-ht7-like receptors functionally linked to cyclic AMP formation. 5-Carboxamidotryptamine (5-CT) and 5-HT enhanced forskolin-stimulated cyclic AMP accumulation in these cells, with pEC50
C Grånäs et al.
European journal of pharmacology, 380(2-3), 171-181 (1999-10-08)
Site-directed mutagenesis of the human 5-HT1B receptor was performed to investigate the role of the amino acid residues cysteine 326 and tryptophan 327 in transmembrane region VI and aspartic acid 352 in transmembrane region VII in ligand binding. Binding studies
Primary neuronal precursors in adult crayfish brain: replenishment from a non-neuronal source
Benton J L, et al.
BMC Neuroscience, 12(1), 53-53 (2011)
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全球贸易项目编号

货号GTIN
MABN177304055977181630
M149-250MG04061834040699
M149-100MG04061834040682