M1547
甲硝唑
BioXtra
别名:
2-甲基-5-硝基咪唑-1-乙醇
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关于此项目
经验公式（希尔记法）:
C6H9N3O3
化学文摘社编号:
分子量:
171.15
UNSPSC Code:
51282808
NACRES:
NA.76
PubChem Substance ID:
EC Number:
207-136-1
Beilstein/REAXYS Number:
611683
MDL number:
product line
BioXtra
Quality Level
impurities
≤0.2% Total Impurities
ign. residue
≤0.1%
color
white to light yellow
mp
159-161 °C (lit.)
solubility
acetic acid: 0.1 M, clear, colorless to yellow
anion traces
chloride (Cl-): ≤0.05%, sulfate (SO42-): ≤0.05%
cation traces
Al: ≤0.0005%, Ca: ≤0.005%, Cu: ≤0.0005%, Fe: ≤0.0005%, K: ≤0.005%, Mg: ≤0.0005%, Na: ≤0.01%, Pb: ≤0.001%, Zn: ≤0.0005%
antibiotic activity spectrum
Gram-negative bacteria, parasites
mode of action
DNA synthesis | interferes
storage temp.
2-8°C
SMILES string
CC1=NC=C([N+]([O-])=O)N1CCO
InChI
1S/C6H9N3O3/c1-5-7-4-6(9(11)12)8(5)2-3-10/h4,10H,2-3H2,1H3
InChI key
VAOCPAMSLUNLGC-UHFFFAOYSA-N
General description
化学结构：咪唑
Application
甲硝唑用于研究DNA损伤和修复，并可诱导猪痢疾密螺旋体（Brachyspira hyodysenteriae）中的基因转移因子VSH-1。 它通常用于治疗牙周炎，并用于生物利用度研究。
Biochem/physiol Actions
甲硝哒唑是一种前药，对厌氧菌具有选择性，因为它们能够在细胞内将甲硝哒唑还原为活性形式。还原甲硝唑与脱氧核糖核酸共价结合，破坏其螺旋结构，诱导脱氧核糖核酸链断裂并抑制细菌核酸合成。最终导致细菌细胞死亡。
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signalword
Danger
hcodes
Hazard Classifications
Carc. 1B - Muta. 1B - STOT RE 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
Tal Frolinger et al.
Scientific reports, 9(1), 3546-3546 (2019-03-07)
Dietary polyphenols promote memory in models of sleep deprivation (SD), stress, and neurodegeneration. The biological properties of dietary polyphenols greatly depend upon the bioavailability of their phenolic metabolites derivatives, which are modulated by gut microbiota. We recently demonstrated that supplementation
Sonja Löfmark et al.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 50 Suppl 1, S16-S23 (2010-01-14)
Metronidazole has been used for the treatment of infections for >45 years and is still successfully used for the treatment of trichomoniasis, amoebiasis, and giardiasis. Anaerobic bacterial infections caused by Bacteroides species, fusobacteria, and clostridia respond favorably to metronidazole therapy.
D Nyasha Chagwedera et al.
Cell metabolism, 30(2), 364-373 (2019-05-28)
Microbial dysbiosis and inflammation are implicated in diet-induced obesity and insulin resistance. However, it is not known whether crosstalk between immunity and microbiota also regulates metabolic homeostasis in healthy animals. Here, we report that genetic deletion of tuberous sclerosis 1
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M1547-25G | 04061834040880 |
| M1547-5G | 04061834040897 |