M264
抗-谷氨酸受体NMDAR2A (NR2A) 兔抗
affinity isolated antibody, lyophilized powder
别名:
NR2A Antibody - Anti-Glutamate Receptor NMDAR2A (NR2A) antibody produced in rabbit, Nr2A Antibody
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, IP, WB
Citations:
18
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
antigen 180 kDa
species reactivity
rat, mouse, human
technique(s)
immunohistochemistry: 1:1,000-1:2,000, immunoprecipitation (IP): 3 μL using 200 μg of rat brain, western blot: 1:1,000
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GRIN2A(2903)
mouse ... Grin2a(14811)
rat ... Grin2a(24409)
General description
N-甲基-D-天门冬胺酸（NMDA）受体复合物由NR1和NR2两类亚基组成。仅有一类NR1亚基尚未被鉴定而NR2A、NR2B、NR2C和NR2D这四种不同的NR2受体亚基均已被鉴定。尽管NR2亚基不会单独发挥功能，它们可以与NR1亚基结合以产生一系列不同的受体类型。一系列研究也表明由NR1和NR2亚基形成的受体复合物的功能属性主要是由复合物的NR2成分所决定的。NMDA受体是在突触后的并会在发育和成熟的中枢神经系统（CNS）的可塑性中起重要作用。NMDA受体的激动剂和拮抗剂已被提出可对多种CNS疾病具有治疗作用，包括中风、头部受伤、癫痫、疼痛和阿尔茨海默症。
抗-谷氨酸受体NMDAR2A（NR2A）多克隆兔抗可对NMDA受体的180 kDa NR2A亚基进行标记。该标记可被抗体与免疫原的预吸附所阻断。抗体不会与NR2B或NR2C亚基发生交叉反应。它与大鼠、小鼠和人体组织发生反应。
Immunogen
NR2A的C末端部分（1253-1391位氨基酸）。
Application
成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质免疫印迹分析（1篇论文）
蛋白质免疫印迹分析（1篇论文）
抗-谷氨酸受体NMDAR2A（NR2A）多克隆兔抗可通过免疫细胞化学和免疫组织化学（IHC）技术，如免疫印迹和免疫沉淀对NMDA的180 kDa NR2A亚基进行检测和定量。它可作为探针用于确定180 kDa NR2A亚基在N-甲基-D-天门冬胺酸（NMDA）受体复合物的组装和功能中的存在和作用。
Physical form
从碳酸氢铵（5 mM）冻干
Other Notes
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Jennifer Stanic et al.
Nature communications, 6, 10181-10181 (2015-12-19)
NMDA receptor (NMDAR) composition and synaptic retention represent pivotal features in the physiology and pathology of excitatory synapses. Here, we identify Rabphilin 3A (Rph3A) as a new GluN2A subunit-binding partner. Rph3A is known as a synaptic vesicle-associated protein involved in
M Cik et al.
The Biochemical journal, 296 ( Pt 3), 877-883 (1993-12-15)
The N-methyl-D-aspartate R1 (NMDAR1) and NMDAR2A subunits were expressed transiently either alone or in combination in human embryonic kidney (HEK) 293 cells. The biochemical and pharmacological properties of the cloned receptors were compared with those of adult rat brain NMDA
Madhumita Yennawar et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(24), 4814-4828 (2019-04-07)
Pathogenic mutations in cyclin-dependent kinase-like 5 (CDKL5) result in CDKL5 deficiency disorder (CDD), a rare disease marked by early-life seizures, autistic behaviors, and intellectual disability. Although mouse models of CDD exhibit dendritic instability and alterations in synaptic scaffolding proteins, studies
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M264-10UG | 04061833385050 |