M265
兔抗N-甲基D-天冬氨酸受体亚型2B多克隆抗体 兔抗
affinity isolated antibody, lyophilized powder
别名:
Anti-DEE27, Anti-EIEE27, Anti-GluN2B, Anti-MRD6, Anti-NMDAR2B, Anti-NR2B, Anti-NR3, Anti-hNR3
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (f), IP, WB
Citations:
8
biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
mol wt
antigen 180 kDa
species reactivity
rat, human, mouse
technique(s)
immunohistochemistry (frozen sections): 1:1,000, immunoprecipitation (IP): 3 μL using 200 μg of rat brain, western blot: 1 μg/mL using 35S-Protein A (with ECL dilutions may be higher)
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... GRIN2B(2904)
mouse ... Grin2b(14812)
rat ... Grin2b(24410)
General description
谷氨酸离子型受体N-甲基-D-天冬氨酸 (NMDA) 亚基2B (GRIN2B) 编码N-甲基D-天冬氨酸r受体亚型2B (GluN2B) 它是N-甲基-D-天冬氨酸受体蛋白的重要组成部分。GRIN2B基因位于人染色体12p13.1。
Immunogen
NR2B的C末端部分（984-1104位氨基酸）。
Application
在兔中生产的抗谷氨酸受体NMDAR2B（NR2B）抗体已被用于蛋白质印迹。
抗谷氨酸受体NMDAR2B（NR2B）抗体适用于免疫组织化学（1:1,000稀释，使用冰冻切片）、免疫沉淀（3μ L，使用200 μg大鼠大脑）和间接ELISA。该抗体也可用于蛋白质印迹（1μg / mL，使用（35S）-蛋白质A）和免疫印迹（180 kDa）。
Biochem/physiol Actions
功能性N-甲基-D-天冬氨酸（NMDA）受体复合物由NMDAR1（NR1）亚基和从NR2A到NR2D之中至少一个NMDAR2亚基组成。 这些受体复合物与耳蜗功能和神经元可塑性有关。NR2B受体的C末端可能调节突触定位。
谷氨酸离子型受体N-甲基-D-天冬氨酸 (NMDA) 亚基2B (GRIN2B) 编码在突触可塑性、语言习得、神经元图式形成（pattern formation）和短期记忆中起关键作用。GRIN2B基因突变会导致帕金森病、精神分裂症、双相障碍、阿尔茨海默症和强迫症。
Physical form
从碳酸氢铵（5 mM）冻干。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
低风险生物材料
常规特殊物品
此项目有
Steve Standley et al.
PloS one, 7(6), e39585-e39585 (2012-07-05)
NMDA receptor NR2A/B subunits have PDZ-binding domains on their extreme C-termini that are known to interact with the PSD-95 family and other PDZ proteins. We explore the interactions between PSD-95 family proteins and the NR2A/B cytoplasmic tails, and the consequences
Meng Suo et al.
Journal of neurophysiology, 116(2), 448-455 (2016-05-06)
Diabetic neuropathy is a common complication of diabetes. This study evaluated the role of Fyn kinase and N-methyl-d-aspartate receptors (NMDARs) in the spinal cord in diabetic neuropathy using an animal model of high-fat diet-induced prediabetes. We found that prediabetic wild-type
D Joelson et al.
Microscopy research and technique, 41(3), 246-262 (1998-05-30)
The distribution of immunoreactivity for the ionotropic N-methyl-D-aspartate (NMDA) receptor subunits was mapped in the cochlear nucleus of postnatal day (P) 7, P14, P21, and P28 gerbils. Frozen sections and serial plastic sections of tissue were incubated with antibodies to
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M265-10UG | 04061834045908 |