M2727
美西律 盐酸盐
≥98% (GC), powder, sodium channel blocker
别名:
1-(2,6-二甲基苯氧基)-2-丙胺 盐酸盐, 1-(2,6-二甲基苯氧基)-2-丙胺盐酸盐 盐酸盐
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关于此项目
经验公式（希尔记法）:
C11H17NO · HCl
化学文摘社编号:
分子量:
215.72
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
250-825-7
MDL number:
产品名称
美西律 盐酸盐, powder
assay
≥98% (GC)
Quality Level
form
powder
color
white to off-white
solubility
methanol: 50 mg/mL
originator
Boehringer Ingelheim
storage temp.
2-8°C
SMILES string
Cl[H].CC(N)COc1c(C)cccc1C
InChI
1S/C11H17NO.ClH/c1-8-5-4-6-9(2)11(8)13-7-10(3)12;/h4-6,10H,7,12H2,1-3H3;1H
InChI key
NFEIBWMZVIVJLQ-UHFFFAOYSA-N
Gene Information
General description
美西律是一种IB类抗心律失常药，是利多卡因的类似物。它的半衰期为10-12小时，在肝脏中代谢，通过还原、氧化或结合反应消除。
Application
盐酸美西律可作为钠离子通道阻滞剂用于：
- 中国仓鼠卵细胞
- 人胚胎肾 (HEK) 细胞，用于全细胞膜片钳研究
- 表达Nav1.7蛋白的HEK细胞的电生理研究
Biochem/physiol Actions
美西律是一种有效的钠离子通道阻滞药。它是一种抗心律失常药，在头疼和神经性疼痛中可作为辅助药物美西律用于治疗钠离子通道病的肌强直症状，并缩短心脏动作电位的去极化时程，但不会对心房不应期造成影响。它对钠通道的抑制作用可有效治疗钾加重性肌强直。
Features and Benefits
该化合物由 Boehringer Ingelheim 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
K Mori et al.
Naunyn-Schmiedeberg's archives of pharmacology, 358(6), 641-648 (1999-01-08)
Recently we have reported that class III antiarrhythmic drugs including amiodarone inhibit the Na+-activated K+ (KNa) channels in isolated cardiac cells. In this study effects of antiarrhythmic drugs having class I and/or IV properties on the single KNa channel current
S Sicouri et al.
Journal of cardiovascular electrophysiology, 8(11), 1280-1290 (1997-12-12)
Recent clinical studies have reported a greater effectiveness of sodium channel block with mexiletine to abbreviate the QT interval in patients with the chromosome 3 variant (SCN5A, LQT3) of the long QT syndrome (LQTS) than those with the chromosome 7
E L Logigian et al.
Neurology, 74(18), 1441-1448 (2010-05-05)
To determine if mexiletine is safe and effective in reducing myotonia in myotonic dystrophy type 1 (DM1). Myotonia is an early, prominent symptom in DM1 and contributes to decreased dexterity, gait instability, difficulty with speech/swallowing, and muscle pain. A few
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M2727-100G | 04061832574851 |
| M2727-25G | 04061834045960 |