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Merck
CN

M3808

MRS 2179 铵盐 水合物

≥98% (HPLC)

别名:

2′--脱氧-N6-甲基腺苷 3′,5′-二磷酸 二铵盐

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关于此项目

经验公式(希尔记法):
C11H17N5O9P2 · xNH3 · yH2O
化学文摘社编号:
分子量:
425.23 (anhydrous free acid basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Quality level:
Storage condition:
desiccated
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Quality Level

assay

≥98% (HPLC)

storage condition

desiccated

solubility

DMSO: 1.1 mg/mL, H2O: >10 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

N.O.CNc1ncnc2n(cnc12)[C@H]3C[C@H](OP(O)(O)=O)[C@@H](COP(O)(O)=O)O3

InChI

1S/C11H17N5O9P2.H3N.H2O/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19;;/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22);1H3;1H2/t6-,7+,8+;;/m0../s1

InChI key

DEQIORFOBOEGKZ-ZJWYQBPBSA-N

Gene Information

human ... P2RY1(5028)

Application

MRS 2179铵盐水合物已用作猪冠状小动脉、内皮细胞和海马星形胶质细胞的P2Y1受体拮抗剂。

Biochem/physiol Actions

MRS 2179具有血小板聚集抑制能力,可防止局部静脉血栓形成,用于治疗血栓综合征。
竞争性P2Y1嘌呤受体拮抗剂。


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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A Baurand et al.
European journal of pharmacology, 412(3), 213-221 (2001-02-13)
The effects of a potent P2Y1 receptor antagonist, N6-methyl-2'-deoxyadenosine-3',5'-bisphosphate (MRS2179) on adenosine-5'-diphosphate (ADP)-induced platelet aggregation in vitro, ex vivo and on the bleeding time in vivo were determined. In suspensions of washed platelets, MRS2179 inhibited ADP-induced platelet shape change, aggregation
Clara Cavelier et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(1), 131-139 (2011-10-08)
Both HDLs and their major protein constituent apolipoprotein A-I (apoA-I) are transported through aortic endothelial cells. The knock-down of the ATP-binding cassette transporters A1 (ABCA1), G1 (ABCG1), and of the scavenger receptor-BI (SR-BI) diminishes but does not completely block the
Manao Kinoshita et al.
EBioMedicine, 32, 72-83 (2018-06-12)
Although psychotropic drugs act on neurons and glial cells, how glia respond, and whether glial responses are involved in therapeutic effects are poorly understood. Here, we show that fluoxetine (FLX), an anti-depressant, mediates its anti-depressive effect by increasing the gliotransmission



全球贸易项目编号

货号GTIN
M3808-25MG04061832091938
M3808-5MG04061832091945