M6545
米托蒽醌 二盐酸盐
≥97% (HPLC)
别名:
1,4-二羟基-5,8-双-[[2-[（2-羟乙基）氨基] 乙基] 氨基]-9,10-蒽二酮 二盐酸盐
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关于此项目
经验公式（希尔记法）:
C22H28N4O6 · 2HCl
化学文摘社编号:
分子量:
517.40
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352005
EC Number:
274-619-1
MDL number:
Assay:
≥97% (HPLC)
Quality level:
Quality Level
assay
≥97% (HPLC)
SMILES string
Cl[H].Cl[H].OCCNCCNc1ccc(NCCNCCO)c2C(=O)c3c(O)ccc(O)c3C(=O)c12
InChI
1S/C22H28N4O6.2ClH/c27-11-9-23-5-7-25-13-1-2-14(26-8-6-24-10-12-28)18-17(13)21(31)19-15(29)3-4-16(30)20(19)22(18)32;;/h1-4,23-30H,5-12H2;2*1H
InChI key
ZAHQPTJLOCWVPG-UHFFFAOYSA-N
Gene Information
human ... TOP2A(7153)
Application
盐酸米托蒽醌已用于：
- 诱导细胞表达钙网蛋白
- 作为遗传毒素剂
- 作为拓扑异构酶抑制剂
Biochem/physiol Actions
米托蒽醌是一种细胞抑制性蒽二酮，可嵌入 DNA 中，通过稳定拓扑异构酶 II 与 DNA 的可裂解复合物，增加双链断裂的发生率。米托蒽醌还表现出广泛的免疫抑制活性，抑制各类淋巴细胞增殖并诱导抗原提呈 T 细胞凋亡。它在临床上用作抗白血病和实体瘤的化疗药物以及多发性硬化症的免疫系统调节剂。
signalword
Danger
hcodes
Hazard Classifications
Muta. 1B - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
商品
DNA损伤和修复机制对于维持DNA完整性至关重要。细胞DNA的损伤与突变、癌症发展等有关。
DNA damage and repair mechanism is vital for maintaining DNA integrity. Damage to cellular DNA is involved in mutagenesis, the development of cancer among others.
Vugar Yagublu et al.
Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 13(1), 79-87 (2013-02-12)
Peritoneal carcinomatosis is a common cause of death in pancreatic cancer patients. In this metastatic stage of the disease, few patients show a sustained response to therapy. In the palliative situation, targeted and compartment restricted delivery of drugs offers the
Yuting Ma et al.
The Journal of experimental medicine, 208(3), 491-503 (2011-03-09)
By triggering immunogenic cell death, some anticancer compounds, including anthracyclines and oxaliplatin, elicit tumor-specific, interferon-γ-producing CD8(+) αβ T lymphocytes (Tc1 CTLs) that are pivotal for an optimal therapeutic outcome. Here, we demonstrate that chemotherapy induces a rapid and prominent invasion
Adi Tzur-Balter et al.
Acta biomaterialia, 9(4), 6208-6217 (2013-01-01)
Nanostructured porous silicon (PSi) thin films, fabricated by the electrochemical anodization of single crystalline Si wafers, are studied as delivery systems for the anticancer drug mitoxantrone dihydrochloride (MTX). The surface chemistry of the PSi carriers was tailored by surface alkylation
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M6545-10MG | 04061834061038 |
| M6545-50MG | 04061834061045 |