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M6690

MDL 28170

Name: MDL 28170
Brand: SIGMA

≥90% (TLC), calpain I and II inhibitor

别名:

钙蛋白酶抑制剂 III

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₆N₂O₄

化学文摘社编号:

88191-84-8

分子量:

382.45

UNSPSC Code:

12352200

PubChem Substance ID:

24278565

NACRES:

NA.77

MDL number:

MFCD00798796

Assay:

≥90% (TLC)

Quality level:

200

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属性

产品名称

MDL 28170, ≥90% (TLC)

Quality Level

200

assay

≥90% (TLC)

composition

Peptide Content, >90%

solubility

DMSO: 26 mg/mL, H₂O: insoluble, methanol: soluble

shipped in

wet ice

storage temp.

2-8°C

SMILES string

[H]C(=O)C(Cc1ccccc1)NC(=O)[C@@H](NC(=O)OCc2ccccc2)C(C)C

InChI

1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)/t19?,20-/m0/s1

InChI key

NGBKFLTYGSREKK-ANYOKISRSA-N

Gene Information

human ... CAPN1(823), CAPN2(824)

说明

Application

MDL 28170已被用作钙蛋白酶抑制剂：

在大鼠心脏骤停模型中研究对神经炎症和坏死的影响
分析对牛肉半膜肌神经元一氧化氮合酶(nNOS)降解的影响
研究对大鼠脑损伤的保护作用及骨髓间充质干细胞在大鼠脑内的存活率

Biochem/physiol Actions

MDL 28170 是一种有效的细胞渗透性钙蛋白酶 I 和 II 抑制剂；减少培养的背根神经节神经元中辣椒素介导的细胞死亡。减少 H₂O₂ 和 A23187 处理的 PC12 细胞凋亡的发生。γ-分泌酶抑制剂。

MDL 28170对大鼠脊髓损伤、局灶性脑缺血和新生儿缺氧缺血均有神经保护作用。它还有抗炎和抗神经退化特性。MDL 28170可穿过血脑屏障，并轻松穿透细胞膜。

有效的细胞渗透性钙蛋白酶 I 和 II 抑制剂；减少培养的背根神经节神经元中辣椒素介导的细胞死亡。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

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货号	GTIN
M6690-25MG	04061834061168