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M9020

美加明 盐酸盐

≥98% (TLC), powder, nAChR antagonist

别名:

2-（甲氨基）异樟烷 盐酸盐, N,2,3,3-四甲基二环 [2.2.1] 庚烷-2-胺 盐酸盐, 盐酸美加明

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关于此项目

经验公式（希尔记法）:
C11H21N · HCl
化学文摘社编号:
826-39-1
分子量:
203.75
NACRES:
NA.77
PubChem Substance ID:
24277851
UNSPSC Code:
12352116
EC Number:
212-555-8
MDL number:
MFCD00151462
Form:
powder
Quality level:
200
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产品名称

美加明 盐酸盐,

form

powder

Quality Level

200

solubility

ethanol: 122 mg/mL, H2O: 47 mg/mL, isopropanol: 476 mg/mL, glycerol: 95 mg/mL

originator

AstraZeneca

SMILES string

Cl.[H][C@@]12CC[C@@]([H])(C1)C(C)(NC)C2(C)C

InChI

1S/C11H21N.ClH/c1-10(2)8-5-6-9(7-8)11(10,3)12-4;/h8-9,12H,5-7H2,1-4H3;1H/t8-,9+,11?;/m1./s1

InChI key

PKVZBNCYEICAQP-CIISUUNXSA-N

Gene Information

human ... CHRNA1(1134), CHRNA10(57053), CHRNA2(1135), CHRNA3(1136), CHRNA4(1137), CHRNA5(1138), CHRNA6(8973), CHRNA7(1139), CHRNA9(55584), CHRNB1(1140), CHRNB2(1141), CHRNB3(1142), CHRNB4(1143)

Application

在电流钳记录期间，美卡拉明盐酸盐已被用作细胞外盐水中的添加剂以减少突触输入。它还被用作主动脉体神经元和 MLO-Y4 细胞中的非选择性烟碱乙酰胆碱受体阻断剂。

Biochem/physiol Actions

非竞争性烟碱乙酰胆碱受体拮抗剂；优先阻断自主神经节的烟碱受体；穿过血脑屏障。

Features and Benefits

该化合物在受体分类和信号转导手册的乙酰胆碱受体（烟碱型）页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
该化合物由 AstraZeneca 公司开发。若要浏览其他制药公司研发的化合物和批准的药物/候选药物列表，请单击此处。

Disclaimer

溶液在高压灭菌时稳定。

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
079M4024V
13190116
019M4108V
13180813
118M4174V

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