M9197
MLCK (1425-1776)，活性，GST 标记 人
PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
别名:
DKFZp686I10125, FLJ12216, KRP, MLCK108, MLCK210, MSTP083, MYLK
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352200
Specific activity:
170-230 nmol/min·mg
Assay:
≥70% (SDS-PAGE)
Recombinant:
expressed in baculovirus infected Sf9 cells
recombinant
expressed in baculovirus infected Sf9 cells
Quality Level
product line
PRECISIO® Kinase
assay
≥70% (SDS-PAGE)
form
buffered aqueous glycerol solution
specific activity
170-230 nmol/min·mg
mol wt
~70 kDa
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... MYLK(4638)
Biochem/physiol Actions
MLCK 或肌球蛋白轻链激酶是免疫球蛋白基因超家族的肌肉成员，是一种钙/钙调蛋白依赖性蛋白激酶。MLCK 是一种平滑肌收缩调节蛋白，通过磷酸化 20-kDa 肌球蛋白轻链 (MLC20) 激活肌球蛋白腺苷三磷酸酶活性发挥作用。磷酸化的激酶活性位于 MLCK 的中心部分，其 N 端具有肌动蛋白结合活性，C 端具有肌球蛋白结合活性。肌球蛋白调节轻链的磷酸化在控制细胞分裂过程中的形态变化中起角色重要作用。
Physical form
50 mM Tris-HCl，pH 7.5，含 150 mM NaCl、0.2 5 mM DTT、0.1 mM EGTA、0.1 mM EDTA、0.1 mM PMSF 和 25% 甘油。
Legal Information
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
F Matsumura et al.
Cell structure and function, 26(6), 639-644 (2002-04-11)
Phosphorylation of regulatory light chain (RMLC) of myosin II at Ser19/Thr18 is likely to play important roles in controlling the morphological changes seen during cell division of cultured mammalian cells. Phosphorylation of RMLC regulates the activity of myosin II, an
Y Gao et al.
IUBMB life, 51(6), 337-344 (2002-01-05)
Myosin light chain kinase (MLCK) is a regulatory protein for smooth muscle contraction, which acts by phosphorylating 20-kDa myosin light chain (MLC20) to activate the myosin ATPase activity. Although this mode of action is well-established, there are numerous reports of
Kasturi Markandran et al.
International journal of molecular sciences, 23(1) (2022-01-12)
Heart failure (HF) as a result of myocardial infarction (MI) is a major cause of fatality worldwide. However, the cause of cardiac dysfunction succeeding MI has not been elucidated at a sarcomeric level. Thus, studying the alterations within the sarcomere
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M9197-10UG | 04061837756108 |