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M9656

H-8 dihydrochloride

Name: H-8 dihydrochloride
Brand: SIGMA

>98% (HPLC)

别名:

N-[2-(Methylamino)ethyl]-5-isoquinolinesulfonamide hydrochloride

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关于此项目

经验公式（希尔记法）:

C₁₂H₁₅N₃O₂S · 2HCl

化学文摘社编号:

113276-94-1

分子量:

338.25

NACRES:

NA.77

PubChem Substance ID:

24278039

UNSPSC Code:

12352200

MDL number:

MFCD00036962

Assay:

>98% (HPLC)

Form:

powder

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属性

assay

>98% (HPLC)

form

powder

storage temp.

2-8°C

SMILES string

Cl[H].Cl[H].CNCCNS(=O)(=O)c1cccc2cnccc12

InChI

1S/C12H15N3O2S.2ClH/c1-13-7-8-15-18(16,17)12-4-2-3-10-9-14-6-5-11(10)12;;/h2-6,9,13,15H,7-8H2,1H3;2*1H

InChI key

RJJLZYZEVNCZIW-UHFFFAOYSA-N

Gene Information

human ... CALCRL(10203), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
rat ... Calcrl(25029)

说明

Biochem/physiol Actions

cAMP and cGMP-dependent protein kinase inhibitor.

Features and Benefits

This compound is featured on the PKA & PKG page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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In vitro activation and nuclear translocation of NF-kappa B catalyzed by cyclic AMP-dependent protein kinase and protein kinase C.

F Shirakawa et al.

Molecular and cellular biology, 9(6), 2424-2430 (1989-06-01)

We have examined whether a precursor form of NF-kappa B, a DNA-binding protein that plays a role in the transcriptional control of several genes, including kappa immunoglobulin light chain and interleukin-2 receptor alpha subunit, could be activated in vitro by

Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

H Hidaka et al.

Biochemistry, 23(21), 5036-5041 (1984-10-09)

Naphthalenesulfonamides such as N-(6-amino-hexyl)-5-chloro-1-naphthalenesulfonamide (W-7) are potent calmodulin (CaM) antagonists and act upon several protein kinases at higher concentration. When the naphthalene ring was replaced by isoquinoline, the derivatives were no longer CaM antagonists but retained the ability to inhibit

全球贸易项目编号

货号	GTIN
M9656-5MG	04061832449012

主要文件

H-8 dihydrochloride

>98% (HPLC)

选择尺寸

关于此项目

assay

form

storage temp.

SMILES string

InChI

InChI key

Gene Information

Biochem/physiol Actions

Features and Benefits

Still not finding the right product?

安全信息

存储类别

wgk

flash_point_f

flash_point_c

ppe

文件

分析证书(COA)

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