M9948
Mirin
≥98% (HPLC), Mre11–Rad50–Nbs1 complex inhibitor, powder
别名:
5-(4-羟基亚苄基)-2-亚氨基噻唑烷-4-酮
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关于此项目
经验公式（希尔记法）:
C10H8N2O2S
化学文摘社编号:
分子量:
220.25
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Mirin, ≥98% (HPLC), powder
Quality Level
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
red to orange
solubility
DMSO: >10 mg/mL
storage temp.
2-8°C
SMILES string
NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2
InChI
1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-
InChI key
YBHQCJILTOVLHD-YVMONPNESA-N
Gene Information
human ... MRE11A(4361)
Application
Mirin已被用作：
- 在辐照前的HCT116野生型细胞预处理中，用作减数分裂重组11（MRE11）的小分子抑制剂
- 作为感染猿猴病毒40的BSC-1细胞的Mre11抑制剂
- 在W12E细胞的预处理中，用于定量人乳头瘤病毒（HPV）附加体水平以及增强聚酰胺-25（PA-25）的作用
Biochem/physiol Actions
Mirin可导致细胞周期阻滞在G1期。 Mirin可增强病毒对抗病毒聚酰胺（AVP）的敏感性。在人乳头瘤病毒（HPV）附加体中，mirin通过形成双链DNA断裂来促进损伤作用。它有助于降低AVP的抑制浓度（IC50）。
Mirin是Mre11-Rad50-Nbs1复合物的抑制剂。
Mirin是Mre11-Rad50-Nbs1复合物的抑制剂。它能够破坏Mre11的核酸酶活性，从而破坏DNA双链断裂修复能力。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
J-Y Wang et al.
Oncogene, 35(13), 1657-1670 (2015-06-23)
DNA repair is critical for the maintenance of genome stability. Upon genotoxic stress, dysregulated DNA repair may induce apoptosis. Translin-associated factor X (TRAX), which was initially identified as a binding partner of Translin, has been implicated in genome stability. However
AKT overactivation can suppress DNA repair via p70S6 kinase-dependent downregulation of MRE11
Piscitello D, et al.
Oncogene, 37(4), 427-427 (2018)
Antiviral activity of pyrrole-imidazole polyamides against SV40 and BK polyomaviruses
Edwards TG and Fisher C
Antiviral Research, 152(4), 68-75 (2018)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M9948-25MG | 04061832722931 |
| M9948-5MG | 04061834064688 |