产品名称
氟尼酸,
biological source
synthetic (organic)
assay
≥98% (HPLC)
form
powder
mp
203-204 °C
solubility
acetone: 50 mg/mL, clear to slightly hazy, yellow
SMILES string
O=C(O)C1=CC=CN=C1NC2=CC(C(F)(F)F)=CC=C2
InChI
1S/C13H9F3N2O2/c14-13(15,16)8-3-1-4-9(7-8)18-11-10(12(19)20)5-2-6-17-11/h1-7H,(H,17,18)(H,19,20)
InChI key
JZFPYUNJRRFVQU-UHFFFAOYSA-N
Gene Information
human ... PTGS1(5742)
Application
尼氟酸已被用于：
- 作为小鼠嗅觉上皮细胞的氯离子通道阻断剂，用于气味诱导的嗅觉电图 （EOG）测量检测其对氨基丁酸诱导后γ大鼠背根神经节神经元的镇痛作用
- 作为C2C12成肌细胞中钙激活性氯离子通道（CaCC）抑制剂，并测试其对体积调节性阴离子通道（VRAC）的影响
- 作为人胚胎肾脏（HEK 293） phoenix细胞中电压依赖性钾通道的抑制剂
Biochem/physiol Actions
尼氟酸（NFA）是一种γA型氨基丁酸受体（GABAAR）拮抗剂，同时也是一种非甾体类抗炎药（NSAID），属于芬那酯（fenamate）类。它还是氯离子通道阻断剂和钙激活性氯离子通道（CaCC）抑制剂。NFA具有抗炎特性，可用于治疗风湿病。它也是N-甲基-D-天冬氨酸受体和甘氨酸受体的抑制剂。NFA还抑制与前列腺素合成相关的酶。
选择性环氧化酶-2 (COX-2) 抑制剂。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Nicholas Baniak et al.
American journal of physiology. Lung cellular and molecular physiology, 303(4), L327-L333 (2012-06-12)
The airway is kept sterile by an efficient innate defense mechanism. The cornerstone of airway defense is mucus containing diverse antimicrobial factors that kill or inactivate pathogens. Most of the mucus in the upper airways is secreted by airway submucosal
Lingye Chen et al.
The Journal of biological chemistry, 294(39), 14279-14288 (2019-08-08)
Skeletal muscle myoblast differentiation involves elaborate signaling networks, including the activity of various ion channels and transporters. Several K+ and Ca2+ channels have been shown to affect myogenesis, but little is known about roles of Cl- channels in the associated
Michele Dibattista et al.
The Journal of general physiology, 140(1), 3-15 (2012-06-27)
The rodent vomeronasal organ plays a crucial role in several social behaviors. Detection of pheromones or other emitted signaling molecules occurs in the dendritic microvilli of vomeronasal sensory neurons, where the binding of molecules to vomeronasal receptors leads to the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N0630-10G | 04061834092933 |
| N0630-25G | 04061834092940 |