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N1413

NSCI

Name: NSCI
Brand: SIGMA

≥97% (HPLC), solid

别名:

1-(4-Methyoxybenzyl)-5-(2-(pyridin-3-yl-oxymethyl)-pyrrolidine-1-sulfonyl)-1H-indole-2,3-dione

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关于此项目

经验公式（希尔记法）:

C₂₆H₂₅N₃O₆S

化学文摘社编号:

872254-32-5

分子量:

507.56

UNSPSC Code:

12352200

PubChem Substance ID:

24897488

NACRES:

NA.77

Assay:

≥97% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥97% (HPLC)

form

solid

solubility

DMSO: >10 mg/mL, H₂O: insoluble

storage temp.

−20°C

SMILES string

COc1ccc(CN2C(=O)C(=O)c3cc(ccc23)S(=O)(=O)N4CCC[C@H]4COc5cccnc5)cc1

InChI

1S/C26H25N3O6S/c1-34-20-8-6-18(7-9-20)16-28-24-11-10-22(14-23(24)25(30)26(28)31)36(32,33)29-13-3-4-19(29)17-35-21-5-2-12-27-15-21/h2,5-12,14-15,19H,3-4,13,16-17H2,1H3/t19-/m0/s1

InChI key

XDHJBIYJRNFDKS-IBGZPJMESA-N

Gene Information

human ... CASP1(834), CASP3(836), CASP6(839), CASP7(840), SUMO1(7341)

说明

Application

NSCI has been used as an apoptosis inhibitor to study its effects on caspase 9 activity in cultured tick cells. It has also been used as an apoptosis inhibitor in terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay to study anti-CD3-induced apoptosis in the cluster of differentiation 4 (CD4⁺) and cluster of differentiation 8 (CD8⁺) T cells from pleural effusions, mononuclear cells (PEMCs).

Biochem/physiol Actions

1-(4-Methoxybenzyl)-5-[2-(pyridin-3-yl-oxymethyl)pyrrolidine-1-sulfonyl]-1H-indole-2,3-dione (NSCI) is a nonpeptide caspase 3 selective inhibitor.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Anaplasma phagocytophilum inhibits apoptosis and promotes cytoskeleton rearrangement for infection of tick cells.

Nieves Ayllón et al.

Infection and immunity, 81(7), 2415-2425 (2013-05-01)

Anaplasma phagocytophilum causes human granulocytic anaplasmosis. Infection with this zoonotic pathogen affects gene expression in both the vertebrate host and the tick vector, Ixodes scapularis. Here, we identified new genes, including spectrin alpha chain or alpha-fodrin (CG8) and voltage-dependent anion-selective

Structural insight on the control of urea synthesis: identification of the binding site for N-acetyl-L-glutamate, the essential allosteric activator of mitochondrial carbamoyl phosphate synthetase.

Satu Pekkala et al.

The Biochemical journal, 424(2), 211-220 (2009-09-17)

NAG (N-acetyl-L-glutamate), the essential allosteric activator of the first urea cycle enzyme, CPSI (carbamoyl phosphate synthetase I), is a key regulator of this crucial cycle for ammonia detoxification in animals (including humans). Automated cavity searching and flexible docking have allowed

全球贸易项目编号

货号	GTIN
N1413-25MG	04061833219713
N1413-5MG	04061834109013