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Merck
CN

N1537

NU7026

≥98% (HPLC), solid

别名:

2-(吗啉-4-基)-苯并[h]铬-4-酮

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关于此项目

经验公式(希尔记法):
C17H15NO3
化学文摘社编号:
分子量:
281.31
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
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Quality Level

assay

≥98% (HPLC)

form

solid

color

tan

solubility

DMSO: soluble 3 mg/mL at 60 °C, H2O: insoluble

shipped in

wet ice

storage temp.

2-8°C

SMILES string

O=C1C=C(Oc2c1ccc3ccccc23)N4CCOCC4

InChI

1S/C17H15NO3/c19-15-11-16(18-7-9-20-10-8-18)21-17-13-4-2-1-3-12(13)5-6-14(15)17/h1-6,11H,7-10H2

InChI key

KKTZALUTXUZPSN-UHFFFAOYSA-N

Application

NU7026 已用于:
  • 作为 DNA 依赖性蛋白激酶(DNA-PK)抑制剂,用于治疗结肠癌细胞
  • 在激酶抑制剂实验中,用于处理在 20 h-人绒毛膜促性腺激素(hCG)后原核可见的受精卵
  • 确定其对 dibenzo[def,p]chrysene 处理 HepG2 细胞的细胞毒性的影响

有效的,ATP 竞争。IC50 = 0.23 μM。对其他 PI3K 相关激酶的选择性(对于 PI3K,IC50 = 13 μM,对于 ATM 和 ATR 为 >100 μM)。

Biochem/physiol Actions

细胞可透过性 DNA-PK(DNA 依赖性蛋白激酶)小分子 benzochromenone 抑制剂。


存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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The influence of ATM, ATR, DNA-PK inhibitors on the cytotoxic and genotoxic effects of dibenzo [def, p] chrysene on human hepatocellular cancer cell line HepG2
Spryszynska S, et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 791, 12-24 (2015)
Sandra Wimberger et al.
Nature communications, 14(1), 4761-4761 (2023-08-15)
Genome editing, specifically CRISPR/Cas9 technology, has revolutionized biomedical research and offers potential cures for genetic diseases. Despite rapid progress, low efficiency of targeted DNA integration and generation of unintended mutations represent major limitations for genome editing applications caused by the
Weiwei Li et al.
Mutation research, 779, 112-123 (2015-07-24)
Although studies have shown that cadmium (Cd) interfered with DNA damage repair (DDR), whether Cd could affect non-homologous end joining (NHEJ) repair remains elusive. To further understand the effect of Cd on DDR, we used X-ray irradiation of Hela cells



全球贸易项目编号

货号GTIN
N1537-5MG04061834109532