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Merck
CN

N1638

制霉菌素悬浮液

suspension, non-animal origin, suitable for cell culture, BioReagent

别名:

Fungicidin, Mycostatin

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关于此项目

化学文摘社编号:
UNSPSC Code:
12352207
PubChem Substance ID:
NACRES:
NA.76
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产品名称

制霉菌素悬浮液, suspension, 10,000 unit/mL in DPBS, BioReagent, suitable for cell culture

product line

BioReagent

Quality Level

form

suspension

concentration

10,000 unit/mL in DPBS

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

yellow

antibiotic activity spectrum

fungi, yeast

mode of action

cell membrane | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\CC\C=C\C=C\[C@H](C)[C@@H](O)[C@@H]1C)O2)C(O)=O

InChI

1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

VQOXZBDYSJBXMA-QEKUPDCNSA-N

General description

化学结构:多烯

Application

制霉菌素悬浮液用于:
  • 抑制陷窝蛋白介导的内吞作用
  • 作为 Eagle′s 最低必需培养基(EMEM)组分
  • 乳酸菌(LAB)计数
  • 防止细胞培养物污染,在表达Toll样受体2(TLR2)的THP1细胞中,诱导白介素(IL)-1、IL-8和肿瘤坏死因子分泌。
该产品用于细胞培养应用的建议浓度为24 mL/L。

Biochem/physiol Actions

制霉菌素是一种多烯类广谱抗生素,可改变脂质筏的微观结构。它可分离真核生物细胞膜上存在的胆固醇。制霉菌素通过细胞因子信号转导、淋巴细胞活化和病原体识别调节免疫应答。

Preparation Note

它已经过0.1μ过滤处理和细胞培养测试。

Other Notes

制霉菌素悬浮液的包装规格有 20 mL和100 mL两种。
保持容器密闭,并置于干燥通风处。打开后的容器必须小心重新密封并保持直立以防止泄漏。

Disclaimer

该产品在37℃下可稳定保存3天。


存储类别

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

农药列管产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Prevent fungal, yeast, and mold contamination in cell cultures. Discover the best antifungal agent for your cultures with the extensive Sigma® antifungal collection.


A method to maintain mammalian cells for days alive at 4 C
Moce-Llivina L and Jofre J
Cytotechnology, 46(1), 57-61 (2004)
Conservation characteristics of corn ears and stover ensiled with the addition of Lactobacillus plantarum MTD-1, Lactobacillus plantarum 30114, or Lactobacillus buchneri 11A44
Lynch JP, et al.
Journal of Dairy Science, 95(4), 2070-2080 (2012)
Liu He et al.
eLife, 9 (2020-04-16)
The development of a polarized neuron relies on the selective transport of proteins to axons and dendrites. Although it is well known that the microtubule cytoskeleton has a central role in establishing neuronal polarity, how its specific organization is established



全球贸易项目编号

货号GTIN
N1638-100ML04061838447302
N1638-20ML04061834109655