N2001
新斯的明
≥98% (HPLC and titration), acetylcholinesterase inhibitor, powder
别名:
3-(N,N-二甲氨基甲酰氧基）-N,N,N,-三甲基苯胺溴化铵, 溴化新斯的明
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
经验公式（希尔记法）:
C12H19BrN2O2
化学文摘社编号:
分子量:
303.20
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
204-054-8
MDL number:
产品名称
新斯的明, ≥98% (HPLC and titration), powder
Quality Level
assay
≥98% (HPLC and titration)
form
powder
color
white
mp
175-177 °C (lit.)
solubility
H2O: 1 g/mL, ethanol: soluble
SMILES string
[Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C
InChI
1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
InChI key
LULNWZDBKTWDGK-UHFFFAOYSA-M
Gene Information
human ... ACHE(43)
Application
溴新斯的明已被用作乙酰胆碱酯酶（AChE）抑制剂:
- 用于控制乙酰胆碱酯酶在史氏菊海鞘（Botryllus schlosseri）冠状器官的反应特异性。
- 用于研究其对幽门环形平滑肌条（PCSMS）异常收缩的影响。
- 用于研究其对袋细胞神经元去极化的影响 。
Biochem/physiol Actions
溴新斯的明是一种季胺。 它通过抑制胆碱酯酶活性而参与延长并增强乙酰胆碱的毒蕈碱和烟碱作用。它在麻醉作用中用于逆转竞争性神经肌肉阻滞剂产生的神经肌肉阻滞。
乙酰胆碱酯酶的可逆抑制剂；不能穿过血脑屏障。
类似于毒扁豆碱的乙酰胆碱酯酶的可逆抑制剂，但是不能穿过血脑屏障。
Features and Benefits
该化合物收录于受体分类和信号转导手册的《乙酰胆碱合成与代谢》页面。想要浏览手册的其他页面， 请单击此处。
Still not finding the right product?
Explore all of our products under 新斯的明
signalword
Danger
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
M Weinstock et al.
The Journal of pharmacology and experimental therapeutics, 218(2), 504-508 (1981-08-01)
The influence of physostigmine was studied on the effect of morphine on the cardiovascular and respiratory systems in conscious rabbits. Morphine (4 mg/kg i.v.) caused analgesia, bradycardia, hypotension and respiratory depression, as indicated by a fall in respiratory rate of
Modified carbon paste sensor for the potentiometric determination of neostigmine bromide in pharmaceutical formulations, human plasma and urine
Khorshid, A F and Issa, Y M
Biosensors And Bioelectronics, 51, 143-149 (2014)
Effect of aurantii fructus immaturus flavonoid on the contraction of isolated gastric smooth muscle strips in rats
Wu Z, et al.
Evidence-Based Complementary and Alternative Medicine : ECAM, 2016(2), 317-328 (2016)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N2001-5G | 04061832948256 |
| N2001-10G | 04061832948249 |
| N2001-1G | 04061834110026 |