N5130
还原型 β-烟酰胺腺嘌呤二核苷酸磷酸 四环己铵盐
≥93%
别名:
NADPH, β-NADPH, 还原型三磷酸吡啶核苷酸, 还原形式的三磷酸吡啶核苷酸
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关于此项目
经验公式（希尔记法）:
C21H30N7O17P3 · 4C6H13N
化学文摘社编号:
分子量:
1142.12
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
Assay:
≥93%
Form:
powder
Storage temp.:
−20°C
Quality Level
assay
≥93%
form
powder
cation traces
Na: ≤0.1%
storage temp.
−20°C
SMILES string
NC1CCCCC1.NC2CCCCC2.NC3CCCCC3.NC4CCCCC4.NC(=O)C5=CN(C=CC5)[C@@H]6O[C@H](COP(O)(=O)OP(O)(=O)OC[C@H]7O[C@H]([C@H](OP(O)(O)=O)[C@@H]7O)n8cnc9c(N)ncnc89)[C@@H](O)[C@H]6O
InChI
1S/C21H30N7O17P3.4C6H13N/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;4*7-6-4-2-1-3-5-6/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);4*6H,1-5,7H2/t10-,11-,13-,14-,15-,16-,20-,21-;;;;/m1..../s1
InChI key
PTKRUDMLGIIORX-ITGWJZMWSA-N
Application
β-烟酰胺腺嘌呤二核苷酸2′-磷酸盐（NADP+）和β-烟酰胺腺嘌呤二核苷酸2′-磷酸还原酶（NADP）包含辅酶氧化还原对（NADP+：NADP），参与多种酶催化氧化还原反应。NADP+/NADPH氧化还原对促进合成代谢反应中的电子转移，如脂质和胆固醇生物合成和脂肪酰基链延长。NADP+/NADPH氧化还原对用于各种抗氧化机制，在这些机制中，它防止活性氧化物质的积累。NADPH是由戊糖磷酸途径（PPP）在体内产生。
Biochem/physiol Actions
电子供体；一氧化氮合成酶的辅因子
Preparation Note
化学还原。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Contribution of Pulmonary CYP-mediated Bioactivation of Naphthalene to Airway Epithelial Injury in the Lung.
Kovalchuk, et al.
Toxicological Sciences, 177, 334-346 (2021)
Xue-Qian Sun et al.
International immunopharmacology, 74, 105634-105634 (2019-06-30)
Heme oxygenase-1 (HO-1) plays a critical protective role in various insults-induced acute lung injury (ALI) through its strong anti-inflammatory, anti-oxidant, and anti-apoptotic properties, but its protective role and mechanism on seawater aspiration-induced acute lung injury remains unclear. This study aimed
Grant R Drummond et al.
Nature reviews. Drug discovery, 10(6), 453-471 (2011-06-02)
NADPH oxidases are a family of enzymes that generate reactive oxygen species (ROS). The NOX1 (NADPH oxidase 1) and NOX2 oxidases are the major sources of ROS in the artery wall in conditions such as hypertension, hypercholesterolaemia, diabetes and ageing
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N5130-25MG | 04061835558032 |