N5751
Nω-硝基-L-精氨酸甲酯 盐酸盐
≥97% (TLC), powder, nitric oxide production inhibitor
别名:
L-NAME HCl, L-NAME 盐酸盐
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关于此项目
经验公式（希尔记法）:
C7H15N5O4 · HCl
化学文摘社编号:
分子量:
269.69
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
257-116-1
MDL number:
Beilstein/REAXYS Number:
3744166
产品名称
Nω-硝基-L-精氨酸甲酯 盐酸盐, ≥97% (TLC), powder
biological source
synthetic
Quality Level
assay
≥97% (TLC)
form
powder
color
white to off-white
mp
132 °C
solubility
H2O: 50 mg/mL
storage temp.
−20°C
SMILES string
Cl.COC(=O)[C@@H](N)CCCNC(=N)N[N+]([O-])=O
InChI
1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChI key
QBNXAGZYLSRPJK-JEDNCBNOSA-N
General description
Nω-硝基-L-精氨酸甲酯盐酸盐或L -NAME HCl，一种抑制NO产生的精氨酸类似物。它对血管系统有多重作用。抑制乙酰胆碱引起的舒张，并引起动脉血压升高。用于预处理小鼠主动脉环制剂时，可取消卵磷脂化超氧化物歧化酶诱导的血管舒张作用。诱导白细胞粘附，增加微血管液以及蛋白质通量和渗透性。还用于许多学习和记忆研究。
Application
Nω-硝基-L-精氨酸甲酯盐酸盐已被用于：
- 研究脑源性神经营养因子对大鼠皮层神经元神经毒性的影响
- 研究其对远红外（FIR）增强大鼠皮肤微循环的影响
- 研究其对瘦素诱导的小鼠肌细胞和脂肪细胞中肌肉因子III型纤连蛋白结构域包含蛋白5/鸢尾素调节的影响
- 研究其对大鼠下丘脑室旁核和视上核细胞内精氨酸加压素和神经元型一氧化氮合酶mRNA水平的影响
Biochem/physiol Actions
抑制NO产生的精氨酸类似物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
DISCOVER Bioactive Small Molecules for Nitric Oxide & Cell Stress Research
L B Zou et al.
Neuropharmacology, 37(3), 323-330 (1998-07-29)
We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained
P Kubes et al.
The American journal of physiology, 262(2 Pt 2), H611-H615 (1992-02-01)
We recently demonstrated that inhibitors of nitric oxide (NO) production cause a dramatic increase in leukocyte adherence and emigration in postcapillary venules. The objective of this study was to assess whether inhibition of NO production leads to vascular protein leakage
Lisa Nguy et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 304(9), R744-R752 (2013-03-22)
Rats with adenine-induced chronic renal failure (A-CRF) develop metabolic and cardiovascular abnormalities resembling those in patients with chronic kidney disease. The aim of this study was to investigate the mechanisms of hypertension in this model and to assess aortic stiffness
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N5751-250MG | 04061834117162 |
| N5751-25G | 04061835521937 |
| N5751-10G | 04061835508976 |
| N5751-1G | 04061835512805 |
| N5751-5G | 04061835558049 |