N6514
神经氨酸酶 来源于霍乱弧菌
Type II, buffered aqueous solution, 8-24 units/mg protein (Lowry, using NAN-lactose)
别名:
受体破坏酶, 唾液酸酶, 神经氨酸苷酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-624-6
MDL number:
Specific activity:
8-24 units/mg protein (Lowry, using NAN-lactose)
Biological source:
Vibrio cholerae
Quality Level
biological source
Vibrio cholerae
type
Type II
form
buffered aqueous solution
specific activity
8-24 units/mg protein (Lowry, using NAN-lactose)
foreign activity
Protease and NAN-aldolase, present
storage temp.
2-8°C
General description
神经氨酸酶是一种促进流感病毒从感染细胞释放并促进病毒传播的水解酶。
量热法研究表明，神经氨酸酶中心催化结构域侧翼的两个凝集素样结构域可作为含唾液酸底物的识别和结合位点。
Application
来自霍乱弧菌的神经氨酸酶已被用于一项描述五步纯化方法的研究中。 它还被用于一项探究白血病L1210肿瘤细胞修饰的研究中。
神经氨酸酶被用作糖缀合物分布和底物特异性研究的细胞表面探针。
Physical form
含有0.15 M 氯化钠及及4 mM 叠氮化钠并经0.2 μm滤器过滤的pH 5.5 50 M 醋酸钠中的溶液。
Preparation Note
通过亲和色谱度我们的III类进行进一步纯化。
Analysis Note
不含防腐剂。
Other Notes
除特殊规定，在37 °C pH 5.0条件下，一个单位可在每分钟内从NAN-乳糖或牛颌下粘蛋白中释放将1.0 μ摩尔的N-乙酰神经氨酸。价格是基于使用NAN-乳糖作为底物的单位。
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signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
高风险级别生物产品--病毒，疫苗等
此项目有
实验方案
在测定神经氨酸酶活性时，使用了一种以N-乙酰新胺酸为酶底物的比色法进行测定。神经氨酸酶是一种可促进流感病毒从感染细胞中释放的水解酶。
Enzymatic Assay of Neuraminidase applies to products that have a specification for neuraminidase content by enzymatic determination.
商品
Understand sialic acid structure, function, signaling, and modifications. Easily find products for sialic acid research.
Purification and Properties of Neuraminidase from Vibrio cholera
Ada, G., et al.
Microbiology, 24, 409-421 (1961)
S Crennell et al.
Structure (London, England : 1993), 2(6), 535-544 (1994-06-15)
Vibrio cholerae neuraminidase is part of a mucinase complex which may function in pathogenesis by degrading the mucin layer of the gastrointestinal tract. The neuraminidase, which has been the target of extensive inhibitor studies, plays a subtle role in the
Ibrahim Moustafa et al.
The Journal of biological chemistry, 279(39), 40819-40826 (2004-07-01)
Vibrio cholerae neuraminidase (VCNA) plays a significant role in the pathogenesis of cholera by removing sialic acid from higher order gangliosides to unmask GM1, the receptor for cholera toxin. We previously showed that the structure of VCNA is composed of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N6514-1UN | 04061834117582 |