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Merck
CN

N6785

还原型 β-烟酰胺腺嘌呤二核苷酸 二钠盐

~98%, pkg of 10 mg (per vial)

别名:

β-DPNH, β-NADH, Coenzyme I reduced 二钠盐, Diphosphopyridine nucleotide reduced 二钠盐

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关于此项目

经验公式(希尔记法):
C21H27N7Na2O14P2
化学文摘社编号:
分子量:
709.40
UNSPSC Code:
41106305
NACRES:
NA.51
PubChem Substance ID:
EC Number:
210-123-3
Beilstein/REAXYS Number:
5230241
MDL number:
Form:
powder
Assay:
~98%
Solubility:
10 mM NaOH: soluble-1 mg/mL, clear, colorless
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assay

~98%

Quality Level

form

powder

packaging

pkg of 10 mg (per vial)

solubility

10 mM NaOH: soluble-1 mg/mL, clear, colorless

SMILES string

[Na+].[Na+].NC(=O)C1=CN(C=CC1)[C@H]2O[C@@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]3O[C@H]([C@H](O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@H](O)[C@@H]2O

InChI

1S/C21H29N7O14P2.2Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(32)14(30)11(41-21)6-39-44(36,37)42-43(34,35)38-5-10-13(29)15(31)20(40-10)27-3-1-2-9(4-27)18(23)33;;/h1,3-4,7-8,10-11,13-16,20-21,29-32H,2,5-6H2,(H2,23,33)(H,34,35)(H,36,37)(H2,22,24,25);;/q;2*+1/p-2/t10-,11+,13-,14+,15-,16+,20-,21+;;/m0../s1

InChI key

QRGNQKGQENGQSE-QUWMEQBESA-L

Application

β-烟酰胺腺嘌呤二核苷酸(NAD+)和还原型 β-烟酰胺腺嘌呤二核苷酸(NADH)构成一个辅酶氧化还原对(NAD +:NADH),参与广泛的酶催化氧化还原反应。除了其氧化还原功能外,NAD+/NADH 是 ADP-核糖基转移酶(ADP-核糖基转移酶;聚(ADP-核糖)聚合酶)反应中的 ADP-核糖单元的供体,也是环状 ADP-核糖(ADP-核糖基环化酶)的前体。

Biochem/physiol Actions

电子供体

Preparation Note

溶液应新鲜制备并及时使用。

Other Notes

根据 UV-Vis 测定的 NADH 含量包装。
这是 NADH 的常见形式;不要与 α 混淆-NADH。


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Arvind Venkat Namuduri et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(2), 2269-2286 (2020-01-08)
SUMOylation is a dynamic, reversible, enzymatic drug-targetable post-translational modification (PTM) reaction where the Small Ubiquitin-like Modifier (SUMO) moieties are attached to proteins. This reaction regulates various biological functions like cell growth, differentiation, and it is crucial for maintaining organ homeostasis.
Xiaoling Li et al.
International journal of biological sciences, 7(5), 575-587 (2011-05-27)
Sirtuins are highly conserved NAD+-dependent protein deacetylases and/or ADP-ribosyltransferases that can extend the lifespan of several lower model organisms including yeast, worms and flies. The seven mammalian sirtuins, SIRT1 to SIRT7, have emerged as key metabolic sensors that directly link
Hening Lin
Organic & biomolecular chemistry, 5(16), 2541-2554 (2007-11-21)
ADP-ribosylation using nicotinamide adenine dinucleotide (NAD+) is an important type of enzymatic reaction that affects many biological processes. A brief introductory review is given here to various ADP-ribosyltransferases, including poly(ADP-ribose) polymerase (PARPs), mono(ADP-ribosyl)-transferases (ARTs), NAD(+)-dependent deacetylases (sirtuins), tRNA 2'-phosphotransferases, and



全球贸易项目编号

货号GTIN
N6785-10VL04061834117711
N6785-1VL04061837143663