O0257
Olvanil
powder
别名:
(N-Vanillyl)-9-oleamide, N-Vannilyloleoylamide
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关于此项目
经验公式（希尔记法）:
C26H43NO3
化学文摘社编号:
分子量:
417.62
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Form:
powder
Quality level:
form
powder
Quality Level
color
white to off-white
solubility
H2O: <0.2 mg/mL, DMSO: 20 mg/mL
storage temp.
−20°C
SMILES string
CCCCCCCC\C=C/CCCCCCCC(=O)NCc1ccc(O)c(OC)c1
InChI
1S/C26H43NO3/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26(29)27-22-23-19-20-24(28)25(21-23)30-2/h10-11,19-21,28H,3-9,12-18,22H2,1-2H3,(H,27,29)/b11-10-
InChI key
OPZKBPQVWDSATI-KHPPLWFESA-N
Gene Information
human ... TRPV1(7442)
Application
Olvanil has been used as a vanilloid (VR1) receptors agonist in rat VR1-transfected human embryonic kidney cells (rVR1-HEK) and dorsal root ganglion (DRG) cells to test its effect on calcium levels.
Biochem/physiol Actions
Olvanil is a vanilloid receptor agonist. It is an analog of capsaicin and is non-pungent. It is an orally active analgesic that alleviates pain by desensitizing nociceptors.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Vincenzo Micale et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 34(3), 593-606 (2008-06-27)
The endocannabinoid-inactivating enzyme, fatty acid amide hydrolase (FAAH), and the transient receptor potential vanilloid type-1 (TRPV1) channel are new targets for the development of anxiolytic drugs. We studied the effect on anxiety-like behavior in the elevated plus maze of a
Edmundo Castillo et al.
Biochemical and biophysical research communications, 356(2), 424-430 (2007-03-17)
Capsaicin (Cap) and its analogs (CAPanalogs) have diverse effects in sensory neurons including analgesia, implying they modulate other cellular targets besides the TRPV1 Cap receptor. Since Cap and CAPanalogs are not largely available and their chemical synthesis is cumbersome, they
Min-Goo Lee et al.
British journal of pharmacology, 146(4), 596-603 (2005-08-02)
Certain fatty acid amides such as anandamide (AEA) and olvanil are agonists for the transient receptor potential, vanilloid-1 (TRPV1) receptor, but have been found to activate TRPV1-containing C-fibers in some tissues but not others. We used extracellular recording and whole-cell
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| O0257-10MG | 04061832557663 |
| O0257-5MG | 04061832557670 |