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Merck
CN

O100

氧化震颤素M

muscarinic acetylcholine receptor agonist, solid

别名:

N,N,N,-三甲基-4-(2-氧代-1-吡咯烷基)-2-丁炔-1-碘化铵, 氧化震颤素甲碘化物

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关于此项目

经验公式(希尔记法):
C11H19IN2O
化学文摘社编号:
分子量:
322.19
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
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产品名称

氧化震颤素M, solid

form

solid

Quality Level

color

white

solubility

H2O: 24 mg/mL, ethanol: 4.6 mg/mL

storage temp.

2-8°C

SMILES string

[I-].C[N+](C)(C)CC#CCN1CCCC1=O

InChI

1S/C11H19N2O.HI/c1-13(2,3)10-5-4-8-12-9-6-7-11(12)14;/h6-10H2,1-3H3;1H/q+1;/p-1

InChI key

VVLMSCJCXMBGDI-UHFFFAOYSA-M

Application

氧化震颤素M已用作毒蕈碱型乙酰胆碱受体(mAchR)激动剂:
  • 用于研究其对秀丽隐杆线虫移动的急性效应
  • 用于处理海马体神经元,以便研究成纤维细胞生长因子受体1(FGFR1)的磷酸化作用
  • 用于诱发大鼠膀胱过度活动症

Biochem/physiol Actions

氧化震颤素M是一种非选择性毒蕈碱型乙酰胆碱受体激动剂。

Features and Benefits

该化合物是《受体分类及信号转导手册》上乙酰胆碱受体(毒蕈硷)乙酰胆碱受体(烟碱)页面上的推荐化合物。想要浏览手册的其他页面, 请单击此处
这种化合物是神经科学研究的特色产品。点击此处发现更多特色神经科学产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。


pictograms

Skull and crossbones

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Wiebke K Seemann et al.
The Journal of pharmacology and experimental therapeutics, 360(2), 289-299 (2017-01-14)
Drug discovery strives for selective ligands to achieve targeted modulation of tissue function. Here we introduce engineered context-sensitive agonism as a postreceptor mechanism for tissue-selective drug action through a G protein-coupled receptor. Acetylcholine M
Simona Dedoni et al.
Journal of neurochemistry, 122(1), 58-71 (2012-04-27)
Type I interferons (IFNs) have been shown to act on neurons and to cause neuronal damage through mechanisms not completely defined. Here, we investigated the effects of type I IFNs on brain-derived neurotrophic factor (BDNF)-induced TrkB receptor signaling and neurotrophic
Paola Correa et al.
PLoS genetics, 8(11), e1003015-e1003015 (2012-11-21)
Caenorhabditis elegans male copulation requires coordinated temporal-spatial execution of different motor outputs. During mating, a cloacal circuit consisting of cholinergic sensory-motor neurons and sex muscles maintains the male's position and executes copulatory spicule thrusts at his mate's vulva. However, distinct



全球贸易项目编号

货号GTIN
O100-100MG04061834212690
O100-500MG04061838065063