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关于此项目
经验公式(希尔记法):
C17H19N3O3S
化学文摘社编号:
分子量:
345.42
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
solid
Quality level:
产品名称
奥美拉唑, solid
form
solid
Quality Level
color
white
solubility
H2O: 0.5 mg/mL, DMSO: >19 mg/mL, ethanol: 4.5 mg/mL
originator
AstraZeneca
storage temp.
2-8°C
SMILES string
COc1ccc2[nH]c(nc2c1)S(=O)Cc3ncc(C)c(OC)c3C
InChI
1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
InChI key
SUBDBMMJDZJVOS-UHFFFAOYSA-N
Gene Information
human ... ABCB1(5243), ATP4A(495), ATP4B(496), CYP1A2(1544)
General description
奥美拉唑是一种苯并咪唑衍生物,弱碱性,并且具有亲脂性。该化合物对pH敏感,在低pH下不以其原始形式存在。
Application
奥美拉唑已在Dulbecco′改良eagle′s培养基(无血清)中用作非典型细胞色素P450(CYP)1A2诱导剂,以研究诱导剂对人肝细胞CYP活性的影响,并与其他经典的芳烃受体配体进行比较。
Biochem/physiol Actions
奥美拉唑可与质子泵发生共价结合(H+,K+-ATPase),并抑制胃分泌。它可用于改善消化性食管炎、十二指肠和胃溃疡的影响。由于其效率更高,因此奥美拉唑更优于组胺H2受体和雷尼替丁的拮抗剂。它也可用于治疗Zollinger-Ellison综合征。
Features and Benefits
该化合物是ADME Tox研究的推荐产品。点击此处查看更多特色 ADME Tox 产品。在sigma.com/discover-bsm 上了解有关生物活性小分子在其他研究领域的更多信息。
该化合物由AstraZeneca开发。要浏览其他药物开发的化合物和已批准药物/候选药物的列表,请单击此处。
Disclaimer
吸湿,光敏
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
商品
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Omeprazole
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M Ritter et al.
British journal of pharmacology, 124(4), 627-638 (1998-08-05)
1. Stimulation of chemotaxis of human polymorphonuclear leucocytes (PMNs) with the chemoattractive peptide fMLP (N-formyl-Met-Leu-Phe) is paralleled by profound morphological and metabolic alterations like changes of intracellular pH (pHi) and cell shape. The present study was performed to investigate the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| O104-100MG | 04061835374786 |
| O104-500MG | 04061835374793 |

