O3636
1H-[1,2,4]恶二唑并[4,3-a]喹恶啉-1-酮
powder
别名:
ODQ
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关于此项目
经验公式（希尔记法）:
C9H5N3O2
化学文摘社编号:
分子量:
187.15
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
assay
≥98% (TLC)
Quality Level
form
powder
color
pale yellow
solubility
ethanol: 1.2 mg/mL, DMSO: 5 mg/mL, H2O: insoluble
storage temp.
2-8°C
SMILES string
O=C1ON=C2C=Nc3ccccc3N12
InChI
1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
InChI key
LZMHWZHOZLVYDL-UHFFFAOYSA-N
Gene Information
human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)
Application
1H-[1,2,4]恶二唑[4,3-a]喹喔啉-1-酮已被用作亲和选择质谱 (AS-MS) 化合物结合检测中的氧化剂 作为可溶性鸟苷酸环化酶 (sGC) 抑制剂用于抑制S-亚硝基-N-乙酰基-DL-青霉胺 (SNAP) 诱导的cGMP生产。
Biochem/physiol Actions
H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮（ODQ）能够非竞争性地抑制一氧化氮敏感性鸟苷酸环化酶的作用，并且可能导致血红素辅基发生不可逆氧化。 ODQ已被用于研究环磷酸鸟苷（cGMP）途径在一氧化氮（NO）信号转导中的作用。
一氧化氮敏感性鸟苷酸环化酶的选择性抑制剂。
Disclaimer
吸湿
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Serena Materazzi et al.
Microvascular research, 109, 38-44 (2016-11-08)
The role of endogenous H2S has been highlighted as a gaseous transmitter. The vascular smooth muscle inhibitory effects of H2S have been characterized in isolated aorta and mesenteric arteries in rats and mice. Our study was aimed at investigating the
Diana Braun et al.
Frontiers in physiology, 9, 480-480 (2018-05-19)
Ischemia/reperfusion injury holds a key position in many pathological conditions such as acute kidney injury and in the transition to chronic stages of renal damage. We hypothesized that besides a reported disproportional activation of vasoconstrictor response, hypoxia/reoxygenation (H/R) adversely affects
Lineu Baldissera et al.
Pulmonary pharmacology & therapeutics, 41, 86-95 (2016-11-07)
Activators of soluble guanylyl cyclase (sGC) act preferentially in conditions of enzyme oxidation or haem group removal. This study was designed to investigate the effects of the sGC activator BAY 60-2770 in murine airways inflammation and human eosinophil chemotaxis. C57Bl/6
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| O3636-25MG | 04061835558216 |
| O3636-5MG | 04061835512867 |