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O7753

草酰乙酸

Name: 草酰乙酸
Brand: SIGMA

powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥97% (HPLC)

别名:

2-氧代丁二酸, 丁酮二酸, 氧代丁二酸, 草醋酸

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关于此项目

线性分子式:

HOOCCH₂COCOOH

化学文摘社编号:

328-42-7

分子量:

132.07

UNSPSC Code:

12352204

NACRES:

NA.75

PubChem Substance ID:

24898047

EC Number:

206-329-8

Beilstein/REAXYS Number:

1705475

MDL number:

MFCD00002592

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属性

biological source

synthetic (organic)

Quality Level

200

product line

BioReagent

assay

≥97% (HPLC)

form

powder

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

solubility

H₂O: 100 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)CC(=O)C(O)=O

InChI

1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9)

InChI key

KHPXUQMNIQBQEV-UHFFFAOYSA-N

说明

General description

草酰乙酸是一种二羧酸，存在于人体的每个细胞中。它是三羧酸（TCA）循环和糖异生的代谢中间体。

Application

草酰乙酸已用于评价对肌萎缩性侧索硬化症（ALS）模型超氧化物歧化酶1 (SOD1) G93A小鼠神经肌肉功能和寿命的影响。它还被用作杜氏改良Eagles培养基（DMEM）的补充剂，用于培养鸡成纤维细胞（DF-1）和化学永生化来角雄性肝癌（LMH）细胞，以进行功能验证实验。

Biochem/physiol Actions

草酰乙酸在中枢代谢中起重要作用。它可抑制琥珀酸脱氢酶，是线粒体代谢的一种关键调节剂。

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pictograms

GHS07

signalword

Warning

hcodes

H319

pcodes

P264 - P280 - P305 + P351 + P338 - P337 + P313

Hazard Classifications

Eye Irrit. 2

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

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Mitochondrial fission in endothelial cells after simulated ischemia/reperfusion: role of nitric oxide and reactive oxygen species.

Randy J Giedt et al.

Free radical biology & medicine, 52(2), 348-356 (2011-11-22)

Ischemia (I)/reperfusion (RP)-induced endothelial cell (EC) injury is thought to be due to mitochondrial reactive oxygen species (mtROS) production. MtROS have been implicated in mitochondrial fission. We determined whether cultured EC exposure to simulated I/RP causes morphological changes in the

Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice.

Randy Strong et al.

The journals of gerontology. Series A, Biological sciences and medical sciences, 68(1), 6-16 (2012-03-28)

The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is

The effects of oxaloacetate on hydrogen peroxide generation from ascorbate and epigallocatechin gallate in cell culture media: potential for altering cell metabolism.

Lee Hua Long et al.

Biochemical and biophysical research communications, 417(1), 446-450 (2011-12-15)

Several phenolic compounds as well as ascorbate can oxidise in certain cell culture media (especially Dulbecco's modified Eagle's medium (DMEM)) to generate hydrogen peroxide. Addition of oxaloacetate decreased the levels of H(2)O(2) detected and the oxaloacetate was depleted. Oxaloacetate was

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全球贸易项目编号

货号	GTIN
O7753-100G	04061834248521
O7753-25G	04061834248538
O7753-5G	04061835514212