O8382
17-十八炔酸
≥95% (GC), Cytochrome P450 epoxygenase inhibitor, powder
别名:
17-ODYA, Alkynyl Stearic Acid, Octadec-17-ynoic acid
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关于此项目
经验公式（希尔记法）:
C18H32O2
化学文摘社编号:
分子量:
280.45
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
17-十八炔酸, ≥95% (GC)
Quality Level
assay
≥95% (GC)
form
powder
solubility
chloroform: 10 mg/mL to clear, colorless to faintly yellow
SMILES string
C#CCCCCCCCCCCCCCCCC(O)=O
InChI
1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h1H,3-17H2,(H,19,20)
InChI key
DZIILFGADWDKMF-UHFFFAOYSA-N
Application
17-十八炔酸可用于脂质合成。
Biochem/physiol Actions
17-十八炔酸 (7-ODYA) 是细胞色素P450同工酶的不可逆抑制剂，参与长链脂肪酸代谢。
选择性和不可逆地抑制细胞色素 P450 环氧酶和 ω-水解酶的自杀底物抑制剂。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
M H Wang et al.
The Journal of pharmacology and experimental therapeutics, 284(3), 966-973 (1998-03-13)
We characterized the inhibitory activity of several acetylenic and olefinic compounds on cytochrome P450 (CYP)-derived arachidonic acid omega-hydroxylation and epoxidation using rat renal cortical microsomes and recombinant CYP proteins. Among the acetylenic compounds, 6-(2-propargyloxyphenyl)hexanoic acid (PPOH) and N-methylsulfonyl-6-(2-propargyloxyphenyl)hexanamide were found
Effects of intrarenal infusion of 17-octadecynoic acid on renal antihypertensive mechanisms in anesthetized rabbits
Evans R G, et al.
American Journal of Hypertension, 11(7), 803-812 (1998)
Kristina Hofmann et al.
Scientific reports, 7(1), 10779-10779 (2017-09-09)
The grey and white matter regions of the mammalian brain consist of both neurons and neuroglial cells. Among the neuroglia, the two macroglia oligodendrocytes and astrocytes are the most abundant cell types. While the major function of oligodendrocytes is the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| O8382-25MG | 04061832785769 |
| O8382-5MG | 04061832785776 |