O9390
N-草酰基甘氨酸
≥98% (HPLC), α-ketoglutarate-dependent enzyme inhibitor, solid
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关于此项目
经验公式（希尔记法）:
C4H5NO5
化学文摘社编号:
分子量:
147.09
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
N-草酰基甘氨酸, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
solid
storage condition
desiccated
solubility
deionized water: >10 mg/mL
storage temp.
2-8°C
SMILES string
OC(=O)CNC(=O)C(O)=O
InChI
1S/C4H5NO5/c6-2(7)1-5-3(8)4(9)10/h1H2,(H,5,8)(H,6,7)(H,9,10)
InChI key
BIMZLRFONYSTPT-UHFFFAOYSA-N
Biochem/physiol Actions
N-草酰甘氨酸是 α-酮戊二酸依赖性酶的抑制剂。
N-草酰甘氨酸是 α-酮戊二酸依赖性酶的抑制剂，并且模仿初始步骤，但不引发羟基化过程。N-草酰甘氨酸已被用于抑制含有 Jumonji C 结构域的组蛋白赖氨酸去甲基化酶。
Features and Benefits
该化合物收录于受体分类和信号转导手册的《谷氨酸/GABA合成与代谢》页面。想要浏览手册的其他页面， 请单击此处。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
谷氨酰胺是谷氨酸和GABA生物合成的常用前体。谷氨酰胺可以利用不同的谷氨酰胺载体在神经元和星形胶质细胞进行细胞内外转运。神经递质谷氨酸可以通过磷酸盐活化的谷氨酰胺酶的作用从谷氨酰胺合成。
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eLife, 9 (2020-03-21)
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Lisa P Elia et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 39(17), 3332-3344 (2019-01-31)
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Nathaniel W Mabe et al.
Cell reports, 33(5), 108341-108341 (2020-11-05)
Dysregulated gene expression is a common feature of cancer and may underlie some aspects of tumor progression, including tumor relapse. Here, we show that recurrent mammary tumors exhibit global changes in gene expression and histone modifications and acquire dependence on
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| O9390-10MG | 04061832632339 |
| O9390-50MG | 04061832632346 |