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P0040

PP1

Name: PP1
Brand: SIGMA

≥98% (HPLC), PTK inhibitor, powder

别名:

4-Amino-5-(methylphenyl)-7-(t-butyl)pyrazolo-(3,4-d)pyrimidine

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关于此项目

经验公式（希尔记法）:

C₁₆H₁₉N₅

化学文摘社编号:

172889-26-8

分子量:

281.36

UNSPSC Code:

12352200

PubChem Substance ID:

329819992

NACRES:

NA.77

MDL number:

MFCD01076570

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

PP1, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: >20 mg/mL

storage temp.

room temp

SMILES string

Cc1ccc(cc1)-c2nn(c3ncnc(N)c23)C(C)(C)C

InChI

1S/C16H19N5/c1-10-5-7-11(8-6-10)13-12-14(17)18-9-19-15(12)21(20-13)16(2,3)4/h5-9H,1-4H3,(H2,17,18,19)

InChI key

ZVPDNRVYHLRXLX-UHFFFAOYSA-N

说明

Application

PP1已用作：

肉瘤(Src)家族激酶(SFK)的抑制剂，如造血细胞激酶(hck)和fyn
在海马神经元培养中选择Src酪氨酸激酶抑制剂以测试其对神经突生长的影响
Src激酶阻滞剂，以测试对溴莫尼定(BMD)诱导的细胞外信号激活激酶(ERK1/2)磷酸化的影响

Biochem/physiol Actions

PP1 是一种有效的选择性 Src 家族蛋白酪氨酸激酶抑制剂。

PP1是一种吡唑嘧啶化合物，作为三磷酸腺苷(ATP)结合的竞争性抑制剂。它还能抑制蛋白酪氨酸激酶(PTK6)，可用于PTK6阳性乳腺癌恶性肿瘤的治疗管理。

Features and Benefits

这种化合物是激酶磷酸酶生物学研究的特色产品。点击此处发现更多特色激酶磷酸酶生物产品。在sigma.com/discover-bsm可了解更多关于其他研究领域中关于生物活性小分子的消息。

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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全球贸易项目编号

货号	GTIN
P0040-25MG	04061833220016
P0040-5MG	04061834262039