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P0099

帕潘立酮

≥98% (HPLC), risperidone metabolite, powder

别名:

3-[2-[4-（6-氟-1,2-苯并异恶唑-3-基）-1-哌啶基] 乙基]-6,7,8,9-四氢-9-羟基-2-甲基-4H-吡啶并 [1,2-a] 嘧啶-4-酮, 9-羟基利培酮

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关于此项目

经验公式（希尔记法）:
C23H27FN4O3
化学文摘社编号:
144598-75-4
分子量:
426.48
UNSPSC Code:
12352200
PubChem Substance ID:
329820012
NACRES:
NA.77
MDL number:
MFCD00871802
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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产品名称

帕潘立酮, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to brown

solubility

DMSO: 2 mg/mL, clear (warmed)

originator

Johnson & Johnson

storage temp.

room temp

SMILES string

CC1=C(CCN2CCC(CC2)c3noc4cc(F)ccc34)C(=O)N5CCCC(O)C5=N1

InChI

1S/C23H27FN4O3/c1-14-17(23(30)28-9-2-3-19(29)22(28)25-14)8-12-27-10-6-15(7-11-27)21-18-5-4-16(24)13-20(18)31-26-21/h4-5,13,15,19,29H,2-3,6-12H2,1H3

InChI key

PMXMIIMHBWHSKN-UHFFFAOYSA-N

Gene Information

human ... DRD2(1813), HTR2A(3356)

Application

帕潘立酮已被用作非典型抗精神病药（AAPD），用于研究其预防脂多糖（LPS）激发的产前免疫小鼠精神疾病的功效。它还被用作非典型抗精神病药（AAPD），用于诠释以细菌内毒素脂多糖（LPS）处理的雌性产前小鼠中下丘脑-垂体-肾上腺（HPA）轴的调节。

Biochem/physiol Actions

帕利哌酮属于非典型抗精神病药；利培酮的活性代谢产物。

Features and Benefits

《受体分类和信号转导》手册的多巴胺受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
该化合物由 强生开发。如需浏览其他制药公司开发的化合物和批准的药物/候选药物列表，请点击此处。

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pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
045M4709V
099K4713
038K47152
038K47151
038K4715

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Studies on animal models provide enough evidences that old age appearance of psychosis on exposures to various insults during critical period of brain development could be prevented by antipsychotic drug treatment. Presently, gestational intervention of the atypical antipsychotic paliperidone (PAL)
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全球贸易项目编号

货号GTIN
P0099-50MG04061832072364
P0099-10MG04061834290803