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P0667

小白菊内酯

Name: 小白菊内酯
Brand: SIGMA

≥98% (HPLC), NF-κB activation inhibitor, powder

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关于此项目

经验公式（希尔记法）:

C₁₅H₂₀O₃

化学文摘社编号:

20554-84-1

分子量:

248.32

UNSPSC Code:

12352200

PubChem Substance ID:

24278621

NACRES:

NA.77

MDL number:

MFCD00134592

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

小白菊内酯, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

mp

115-116 °C (lit.)

storage temp.

2-8°C

SMILES string

C/C(CC[C@]12[H])=C/CC[C@]3(C)[C@H](O3)[C@]1(OC(C2=C)=O)[H]

InChI

1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5-/t11-,12-,13+,15+/m0/s1

InChI key

KTEXNACQROZXEV-ZRPLFPEYSA-N

Gene Information

human ... ELA2(1991), IKBKG(8517), NFKB1(4790), NKAP(79576), NKRF(55922)

说明

Application

小白菊內酯已用于：

与vasohibin 1（血管生成抑制蛋白）结合形成晶体，以便研究微管蛋白脱酪氨酸化抑制机制
作为核因子活化B细胞(NF-κB)κ-轻链增强子的抑制剂，以及信号转导和转录活化因子(STAT)的抑制剂，研究其对CD36结合恶性疟原虫感染红细胞(IECD36)的细胞粘附的影响
作为亲脂试剂，研究其对外周血来源的CD8⁺T细胞生产白介素13和干扰素γ的影响

Biochem/physiol Actions

小白菊內酯(Parthenolide)是一种倍半萜内酯，丰富存在于小白菊叶和花中。小白菊內酯具有抗癌特性，可用于治疗侵袭性癌症。小白菊內酯也可用来治疗炎症和偏头痛。它可在信号转导和转录活化因子(STAT)抑制介导的促凋亡基因转录抑制中起作用。

抑制 NF-κB 活化的抗炎剂。

Other Notes

野甘菊 ( Tanacetum parthenium ) 和其他植物中发现的倍半萜内酯。

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pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P280 - P302 + P352

Hazard Classifications

Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Parthenolide (PTL), a sesquiterpene lactone (SL) originally purified from the shoots of feverfew (Tanacetum parthenium), has shown potent anticancer and anti-inflammatory activities. It is currently being tested in cancer clinical trials. Structure-activity relationship (SAR) studies of parthenolide revealed key chemical

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全球贸易项目编号

货号	GTIN
P0667-5MG	04061834353003
P0667-25MG	04061834352990