P0913
聚肌苷酸-聚胞苷酸 钠盐
γ-irradiated, 10% Poly (I:C) with buffer salts, TLR ligand tested
别名:
Poly (I:C), Poly(I) • Poly(C)
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
Assay:
≥99% (less than 1% free nucleotides, TLC)
Biological source:
synthetic (organic)
Form:
lyophilized powder
Solubility:
H2O: 10 mg/mL
Storage temp.:
−20°C
biological source
synthetic (organic)
Quality Level
sterility
γ-irradiated
assay
≥99% (less than 1% free nucleotides, TLC)
form
lyophilized powder
storage condition
desiccated
solubility
H2O: 10 mg/mL
storage temp.
−20°C
SMILES string
[Na].[P](=O)(OC[C@H]3O[C@H]([C@@H]([C@@H]3O)O)[n]4c5ncnc(c5nc4)O)(O)O.[P](=O)(OC[C@H]1O[C@H]([C@@H]([C@@H]1O)O)N2C=CC(=NC2=O)N)(O)O
InChI
1S/C10H13N4O8P.C9H14N3O8P.Na/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);/t
InChI key
GETQKWBYQAUFQM-VRQAYDGLSA-N
Application
TLR3可识别双链RNA并作为应对病毒病原体免疫反应的一种主要效应子。 聚肌胞苷-聚胞苷酸（Poly(I) • Poly(C)）是一种可作为在TLR3水平对细胞信号转导进行研究的模型RNA的双链均聚物。 Poly(IC)是一种TRIF依赖性toll样受体-3（TLR3）配体。
Biochem/physiol Actions
将Poly(I:C)转染至NIT-1细胞中，已被用作细胞内dsRNA诱导的β细胞凋亡的模型。转染后18小时，45％的细胞发生凋亡，并且其NF-kB、p50/p65核转位、caspase 3和8切割以及caspase 12的转录诱导、Fas、IL-15和TNF受体相关配体（TRAIL）水平均增加。有人提出Poly(I:C)是最合适的稳定成熟树突状细胞（DC）诱导剂之一。这些成熟DC能够在CD40连接后分泌生物活性IL-12，因此注射后能够在体内产生有效的免疫应答。Poly(I:C)被用作有效的佐剂，以增强对肽类疫苗的特异性抗肿瘤免疫应答。
Preparation Note
本品需要离子强度，以维持双链结构。为了防止变形，可用生理性盐溶度（如盐水溶液）的溶液将其重悬。重悬过程可能需要加热（50 °C）及冷却以实现重新退火。
Other Notes
双链均聚物。
Still not finding the right product?
Explore all of our products under 聚肌苷酸-聚胞苷酸 钠盐
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Joao N Duarte et al.
Journal of immunology (Baltimore, Md. : 1950), 197(12), 4838-4847 (2016-11-09)
mAbs specific for surface proteins on APCs can serve as Ag-delivery vehicles that enhance immunogenicity. The practical use of such constructs is limited by the challenge of expressing and modifying full-sized mAbs. We generated single-domain Ab fragments (VHHs) specific for
Xi Xue et al.
Cells, 8(12) (2019-12-11)
MicroRNAs (miRNAs) are key regulators in fish immune responses. However, no study has previously characterized the impact of polyriboinosinic polyribocytidylic acid (pIC) and formalin-killed typical Aeromonas salmonicida (ASAL) on miRNA expression in Atlantic salmon fed a commercial diet with and
Dan-Dan Tu et al.
Fish & shellfish immunology, 69, 119-127 (2017-07-27)
Peroxiredoxin 5 (Prx5) belongs to a novel family of evolutionarily conserved antioxidant proteins that protect cells against various oxidative stresses. Generally, no more than one Prx5 transcript had been reported in non-primate species. In this study, two Prx5 genes (coined
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P0913-10MG | 04061834353263 |
| P0913-50MG | 04061834353270 |