P1024
聚-D-赖氨酸 氢溴酸盐
suitable for cell culture, Mol wt ≥300,000
别名:
D-Lysine homopolymer hydrobromide
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关于此项目
线性分子式:
D-Lys-(D-Lys)n-D-Lys · xHBr
化学文摘社编号:
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:
产品名称
聚-D-赖氨酸 氢溴酸盐, mol wt ≥300,000
form
powder or solid
Quality Level
mol wt
≥300,000
technique(s)
cell culture | mammalian: suitable
color
white to off-white
storage temp.
−20°C
SMILES string
O=C(C)[C@@](NC)([H])CCCCN.[Br]
InChI
1S/C6H14N2O2.BrH/c7-4-2-1-3-5(8)6(9)10;/h5H,1-4,7-8H2,(H,9,10);1H
InChI key
MEXAGTSTSPYCEP-UHFFFAOYSA-N
Application
聚-D-赖氨酸聚合物可用于制备细胞附着的表面。D-赖氨酸聚合物也可用于消化聚-L-赖氨酸聚合物并导致L-赖氨酸过量摄取的细胞。
建议使用0.5 - 1.0 mL的该产品0.1 mg/mL溶液用作细胞培养的基质对25 cm2进行涂覆。 较低分子量的该产品粘度相对较低，但较高分子量的形式则可提供每分子更多的附着位点。
建议使用0.5 - 1.0 mL的该产品0.1 mg/mL溶液用作细胞培养的基质对25 cm2进行涂覆。 较低分子量的该产品粘度相对较低，但较高分子量的形式则可提供每分子更多的附着位点。
Biochem/physiol Actions
多聚-L-赖氨酸（PDL）氢溴酸盐是细胞的非特异性粘附因子，它通过增强细胞膜表面的负电荷离子与培养表面之间的静电相互作用，促进细胞与固相基质的粘附。 当被细胞培养表面吸收后，聚-D-赖氨酸可增加带正电的细胞结合位点数量。
Preparation Note
本品分子量 > 30 万。为除去 HBr，将本品溶于中性缓冲液中，透析除去盐类。一般以本品为附着因子，在 5 mg 聚赖氨酸中加入 50 mL 无菌组织培养级水，每 25 cm2 溶液无菌涂布表面 1 mL。5 min 后，通过抽吸清除溶液，并彻底冲洗表面。在引入细胞和培养基前干燥两小时。
Other Notes
聚-D-赖氨酸是一种带正电的氨基酸聚合物，其中每个赖氨酸残基约有一个HBr。 氢溴酸盐可使聚-D-赖氨酸呈可溶于水的结晶形式。 在β结构中可能会发现少量的产物，因为HBr干扰氨基与羧基或含N或O部分之间的氢键。
Disclaimer
无菌溶液可在2-8℃条件下稳定保存2年。脱水保存在-20°C条件下。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
商品
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全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P1024-10MG | 04061832778945 |
| P1024-50MG | 04061834353850 |
| P1024-100MG | 04061834353829 |
| P1024-1G | 04061826757420 |
| P1024-500MG | 04061832778952 |